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Study Information
Study Attribute Value
CEBS Accession Number: 002-01058-0002-0000-8
Chemical Name: 1,2-Epoxybutane
CASRN: 106-88-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 333393_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Weakly Positive 
No Activation  2  Weakly Positive* 
Induced Rat Liver S9  2_S9  Negative 
Induced Rat Liver S9  3_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/13/1984    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Epoxybutane 
16         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
50         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
160         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
500         
 40 8 0.200 18.0 2 0.050 5.0 6 0.150 15.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 24 0.240 21.0 14 0.140 12.0 10 0.100 9.0 0 0.000 0.0
Mitomycin-C 
1         
 50 19 0.380 34.0 11 0.220 22.0 8 0.160 16.0 0 0.000 0.0
Trend: 3.324 1.719 3.165  
Probability: 0.000 0.043 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/12/1984    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2-Epoxybutane 
50         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
160         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
750         
 100 14 0.140 13.0 9 0.090 8.0 4 0.040 4.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
15         
 100 16 0.160 13.0 7 0.070 5.0 9 0.090 9.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 25 0.500 38.0 21 0.420 30.0 4 0.080 8.0 0 0.000 0.0
Trend: 3.131 2.518 1.536  
Probability: 0.001 0.006 0.062  


Trial #:2   Activation: No Activation    Date: 01/18/1984    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 1,2-Epoxybutane 
16         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
50         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
160         
 100 13 0.130 7.0 5 0.050 3.0 7 0.070 3.0 1 0.010 1.0 
500         
 56 10 0.179 16.0 4 0.071 7.0 5 0.089 9.0 1 0.018 1.0 
1600         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 33 0.330 30.0 9 0.090 9.0 24 0.240 21.0 0 0.000 0.0
Mitomycin-C 
1         
 50 18 0.360 26.0 6 0.120 12.0 12 0.240 18.0 0 0.000 0.0
Trend: 3.364 2.835 1.792  
Probability: 0.000 0.002 0.037  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 02/16/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: 1,2-Epoxybutane 
16         
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0 
50         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
160         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 9 0.090 6.0 5 0.050 4.0 4 0.040 4.0 0 0.000 0.0 
750         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 25 0.250 21.0 15 0.150 12.0 10 0.100 10.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 27 0.540 40.0 14 0.280 22.0 13 0.260 22.0 0 0.000 0.0
Trend: 0.204 1.093 0.755  
Probability: 0.419 0.137 0.225  


Trial #:3_S9   Activation: Induced Rat Liver S9    Date: 01/17/1984    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2-Epoxybutane 
16         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
50         
 100 6 0.060 3.0 2 0.020 1.0 4 0.040 3.0 0 0.000 0.0 
160         
 100 8 0.080 7.0 5 0.050 5.0 3 0.030 3.0 0 0.000 0.0 
500         
 200 12 0.060 6.0 4 0.020 2.0 8 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 14 0.140 13.0 4 0.040 4.0 10 0.100 9.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 28 0.560 42.0 3 0.060 6.0 25 0.500 40.0 0 0.000 0.0
Trend: 1.450 0.695 1.284  
Probability: 0.074 0.244 0.100