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Study Information
Study Attribute Value
CEBS Accession Number: 002-01058-0011-0000-8
Chemical Name: 1,2-Epoxybutane
CASRN: 106-88-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 119097
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 75 105 61 27 30
    85 95 71 28
    76 122 51 22
    66 78 86 44
Test Chemical 1,2-Epoxybutane 
50         
 60 88 80 44 38
    86 95 83 32
  
100         
 85 92 75 29 36
    59 71 77 43
  
200         
 87 79 120 46 41
    85 83 90 35
  
400         
 82# 80 267 109 121*
    21 28 82 132
Positive Control Ethyl Methane Sulfonate 
250         
 74 66 366 165 173*
    58 54 317 181

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 50 87 121 80 69
    65 116 88 45
    68 99 124 61
    60 98 163 91
Test Chemical 1,2-Epoxybutane 
50         
 62 105 112 61 65
    65 97 135 70
  
100         
 43 73 103 80 65
    61 115 90 49
  
200         
 68 102 156 77 83
    64 106 171 89
  
400         
 69 102 230 111 109*
    58 84 188 108
  
800         
 48 46 775 544 492*
    34 49 453 440
Positive Control Ethyl Methane Sulfonate 
250         
 48 64 497 349 311*
    54 76 443 273

Induced S9 Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 81 82 65 27 34
    82 95 96 39
    86 109 68 26
    86 114 117 46
Test Chemical 1,2-Epoxybutane 
50         
 61 91 32 17 21
    80 108 59 25
  
100         
 76 103 60 26 38
    66 94 97 49
  
200         
 26 39 48 62 57*
    54 64 86 53
  
400         
 43 50 107 83 65*
    69 67 98 47
  
800         
 28 21 160 194 348*
    13 8 193 501
  
1600         
   
Positive Control 3-Methylcholanthrene 
2.5       
 40 25 442 370 368*
    43 19 468 366

Induced S9 Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 95 87 206 73 68
    95 93 185 65
    98 106 229 78
    108 114 181 56
Test Chemical 1,2-Epoxybutane 
50         
 97 76 161 55 48
    86 63 107 41
  
100         
 76 78 129 57 55
    87 73 137 53
  
200         
 86 58 205 79 79
    87 71 205 79
  
400         
 81 48 380 157 161*
    71 46 351 166
  
800         
 48 10 655 452 559*
    34 8 672 665
  
1600         
   
Positive Control 3-Methylcholanthrene 
2.5       
 83 61 584 235 303*
    70 38 775 371

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination