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Study Information
Study Attribute Value
CEBS Accession Number: 002-01058-0013-0000-0
Chemical Name: 1,2-Epoxybutane
CASRN: 106-88-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: G71732
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 85 101 89 35 47
    83 99 149 60
Test Chemical 1,2-Epoxybutane 
 0.174     
 93 88 221 79 83*
    88 86 231 88
  
 0.204     
 79 65 288 121 110*
    94 79 276 98
  
 0.24      
 85 67 286 112 115*
    82 67 290 119
  
 0.283     
 84 60 358 142 145*
    82 65 365 148
  
 0.333     
 84 55 406 161 166*
    74 48 378 171
  
 0.392     
 65 38 436 223 230*
    64 40 454 236
  
 0.461     
 63 30 496 263 262*
    58 28 455 261
  
 0.542     
 41 15 483 394 363*
    45 16 445 332
  
 0.638     
 33 8 396 404 441*
    29 7 418 478
  
 0.75      
 22 4 331 505 511*
    20 4 310 517
Positive Control Ethyl Methane Sulfonate 
500         
 54 40 904 556 584*
    49 40 897 612

Induced S9 Trial: 1 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 96 101 316 110 111
    90 99 304 112
Test Chemical 1,2-Epoxybutane 
 0.066     
 66 40 451 228 238*
    66 40 489 247
  
 0.077     
 54 29 612 379 347*
    60 32 561 314
  
 0.091     
 41 16 575 467 424*
    45 15 514 381
  
 0.107     
 33 8 499 509 535*
    29 7 479 560
  
 0.126     
 23 5 428 611 580*
    26 4 433 548
  
 0.148     
 21 3 321 518
   
  
 0.174     
   
Positive Control 3-Methylcholanthrene 
5         
 86 64 540 208 239*
    66 52 538 270

Induced S9 Trial: 3 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 112 106 175 52 60
    117 109 193 55
    109 103 208 63
    89 83 191 71
Test Chemical 1,2-Epoxybutane 
 0.037     
 94 77 274 97 98*
    84 77 250 99
  
 0.044     
 96 88 260 90 98*
    106 86 337 106
  
 0.051     
 94 80 361 128 106*
    94 78 236 84
  
 0.06      
 108 93 266 82 81
    87 76 208 80
  
 0.071     
 93 66 351 126 119*
    96 71 322 112
  
 0.084     
 103 69 405 132 146*
    77 54 374 161
  
 0.098     
 80 49 450 187 186*
    84 49 468 185
  
 0.116     
 78 34 542 233 229*
    74 32 497 225
  
 0.136     
 55 13 609 372 357*
    65 17 667 341
  
 0.16      
 43 6 619 485 510*
    36 5 575 535
Positive Control 3-Methylcholanthrene 
5         
 78 45 709 302 321*
    73 42 719 328
    68 32 680 333

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination