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Study Information
Study Attribute Value
CEBS Accession Number: 002-01061-0001-0000-1
Chemical Name: 1,2-Epoxyhexadecane
CASRN: 7320-37-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 584750_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/02/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1038 377 0.363 7.54 26.0 -0.217
Ethanol 
0         
 50 1033 376 0.364 7.52 26.0 0.000
Test Chemical 1,2-Epoxyhexadecane 
1.7       
 50 1042 402 0.386 8.04 26.0 5.991 
5         
 50 1037 407 0.392 8.14 26.0 7.827 
17         
 50 1028 360 0.350 7.20 26.0 -3.790 
50         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1026 569 0.555 11.38 26.0 52.362
Mitomycin-C 
 0.01      
 5 101 191 1.891 38.20 26.0 419.547
Trend: -0.444        
Probability: 0.671        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/02/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1030 468 0.454 9.36 26.0 0.000
Negative (Not Specified) 
0         
 50 1028 352 0.342 7.04 26.0 -24.640
Test Chemical 1,2-Epoxyhexadecane 
5         
 50 1037 494 0.476 9.88 26.0 4.843 
17         
 50 1031 549 0.532 10.98 26.0 17.194 
50         
 50 1033 520 0.503 10.40 26.0 10.788 
167         
 50 1034 501 0.485 10.02 26.0 6.637 
500         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1041 590 0.567 11.80 26.0 24.736
Cyclophosphamide 
2         
 5 103 158 1.534 31.60 26.0 237.607
Trend: 1.288        
Probability: 0.099