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Study Information
Study Attribute Value
CEBS Accession Number: 002-01061-0002-0000-2
Chemical Name: 1,2-Epoxyhexadecane
CASRN: 7320-37-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 584750_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/25/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Ethanol
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Epoxyhexadecane
10         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
20         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
30         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
40         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.04      
100 19 0.190 15.0 11 0.110 10.0 8 0.080 7.0 0 0.000 0.0
Mitomycin-C
 0.0625    
25 11 0.440 36.0 7 0.280 24.0 4 0.160 16.0 0 0.000 0.0
Trend: 1.799 1.270 1.270  
Probability: 0.036 0.102 0.102  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/25/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Ethanol
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Epoxyhexadecane
402         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
498         
100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
600         
100 2 0.020 1.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide
12.5       
100 19 0.190 17.0 9 0.090 9.0 10 0.100 9.0 0 0.000 0.0
Cyclophosphamide
62.5       
25 9 0.360 24.0 6 0.240 20.0 3 0.120 12.0 0 0.000 0.0
Trend: 1.401 1.281 1.331  
Probability: 0.081 0.100 0.092