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Study Information
Study Attribute Value
CEBS Accession Number: 002-01061-0003-0000-3
Chemical Name: 1,2-Epoxyhexadecane
CASRN: 7320-37-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 818134_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Questionable 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 
Induced Rat Liver S9  3_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 04/10/1984    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 409 0.393 8.18 26.0 8.149
Ethanol 
0         
 50 1045 380 0.364 7.60 26.0 0.000
Test Chemical 1,2-Epoxyhexadecane 
 0.16      
 50 1049 464 0.442 9.28 26.0 21.640 
 0.5       
 50 1045 403 0.386 8.06 26.0 6.053 
1.6       
 50 1043 390 0.374 7.80 26.0 2.828 
5         
 50 1041 398 0.382 7.96 26.0 5.139 
16         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1044 1320 1.264 26.40 26.0 247.701
Mitomycin-C 
 0.01      
 10 208 629 3.024 62.90 26.0 731.611
Trend: -0.510        
Probability: 0.695        

Trial #: 2    Activation: No Activation    Date: 06/12/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 453 0.433 9.06 27.0 4.197
Ethanol 
0         
 50 1049 436 0.416 8.72 27.0 0.000
Test Chemical 1,2-Epoxyhexadecane 
 0.5       
 50 1050 438 0.417 8.76 27.0 0.363 
1.6       
 50 1048 446 0.426 8.92 27.0 2.391 
5         
 50 1048 424 0.405 8.48 27.0 -2.659 
10         
 50 1050 449 0.428 8.98 27.0 2.884 
20         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 929 0.885 18.58 27.0 112.870
Mitomycin-C 
 0.01      
 10 209 692 3.311 69.20 27.0 696.616
Trend: 0.130        
Probability: 0.448        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/10/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1043 421 0.404 8.42 26.0 0.000
Negative (Not Specified) 
0         
 50 1048 486 0.464 9.72 26.0 14.889
Test Chemical 1,2-Epoxyhexadecane 
1.6       
 50 1045 522 0.500 10.44 26.0 23.753 
5         
 50 1050 572 0.545 11.44 26.0 34.961 
16         
 50 1051 589 0.560 11.78 26.0 38.840 
50         
 50 1042 664 0.637 13.28 26.0 57.871 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1046 623 0.596 12.46 26.0 47.557
Cyclophosphamide 
2         
 10 210 320 1.524 32.00 26.0 277.514
Trend: 7.410        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/12/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1043 455 0.436 9.10 26.0 0.000
Test Chemical 1,2-Epoxyhexadecane 
10         
 50 1051 459 0.437 9.18 26.0 0.111 
25         
 50 1048 513 0.490 10.26 26.0 12.209 
50         
 50 1052 507 0.482 10.14 26.0 10.475 
75         
 14 288 209 0.726 14.93 26.0 66.351 
100         
 9 187 108 0.578 12.00 31.0 32.390 
125         
 17 354 233 0.658 13.71 31.0 50.878
Positive Control Cyclophosphamide 
 0.3       
 50 1048 533 0.509 10.66 26.0 16.584
Cyclophosphamide 
2         
 0 0 0 0.000 0.00 0.0 N/A
Trend: 6.417        
Probability: 0.000        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 07/10/1984    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1051 599 0.570 11.98 27.0 0.000
Negative (Not Specified) 
0         
 50 1052 417 0.396 8.34 27.0 -30.450
Test Chemical 1,2-Epoxyhexadecane 
75         
 50 1045 683 0.654 13.66 26.0 14.678 
100         
 50 1047 591 0.564 11.82 26.0 -0.959 
125         
 50 1040 637 0.613 12.74 26.0 7.469 
150         
 50 1047 682 0.651 13.64 26.0 14.291
Positive Control Cyclophosphamide 
 0.3       
 50 1052 765 0.727 15.30 27.0 27.591
Cyclophosphamide 
2         
 10 210 493 2.348 49.30 27.0 311.911
Trend: 1.425        
Probability: 0.077