Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01065-0001-0000-5 |
Chemical Name: | 1,2-Propylene oxide |
CASRN: | 75-56-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 772114_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1048 | 471 | 0.449 | 9.42 | 26.5 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1047 | 455 | 0.435 | 9.10 | 26.5 | -3.305 | |
Test Chemical | 1,2-Propylene oxide | 1.6 | 50 | 1051 | 565 | 0.538 | 11.30 | 26.5 | 19.615 |
5 | 50 | 1044 | 764 | 0.732 | 15.28 | 26.5 | 62.830 | ||
16 | 50 | 1044 | 1144 | 1.096 | 22.88 | 26.5 | 143.818 | ||
50 | 50 | 1046 | 2677 | 2.559 | 53.54 | 26.5 | 469.452 | ||
160 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1046 | 536 | 0.512 | 10.72 | 26.5 | 14.018 |
Mitomycin-C | 0.01 | 50 | 1047 | 2586 | 2.470 | 51.72 | 26.5 | 449.569 | |
Trend: | 47.153 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1043 | 436 | 0.418 | 8.72 | 26.0 | -0.398 |
Dimethyl Sulfoxide | 0 | 50 | 1046 | 439 | 0.420 | 8.78 | 26.0 | 0.000 | |
Test Chemical | 1,2-Propylene oxide | 5 | 50 | 1041 | 681 | 0.654 | 13.62 | 26.0 | 55.870 |
16 | 50 | 1041 | 941 | 0.904 | 18.82 | 26.0 | 115.380 | ||
50 | 50 | 1045 | 2047 | 1.959 | 40.94 | 26.0 | 366.733 | ||
100 | 50 | 1048 | 2533 | 2.417 | 50.66 | 26.0 | 475.892 | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1046 | 1402 | 1.340 | 28.04 | 26.0 | 219.362 |
Mitomycin-C | 0.01 | 10 | 211 | 693 | 3.284 | 69.30 | 26.0 | 682.561 | |
Trend: | 47.801 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1046 | 450 | 0.430 | 9.00 | 26.5 | -9.914 |
Dimethyl Sulfoxide | 0 | 50 | 1047 | 500 | 0.478 | 10.00 | 26.5 | 0.000 | |
Test Chemical | 1,2-Propylene oxide | 16 | 50 | 1052 | 513 | 0.488 | 10.26 | 26.5 | 2.112 |
50 | 50 | 1043 | 696 | 0.667 | 13.92 | 26.5 | 39.734 | ||
160 | 50 | 1046 | 1047 | 1.001 | 20.94 | 26.5 | 109.600 | ||
500 | 50 | 1044 | 2881 | 2.760 | 57.62 | 26.5 | 477.856 | ||
1600 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.3 | 50 | 1047 | 450 | 0.430 | 9.00 | 26.5 | -10.000 |
Cyclophosphamide | 2 | 50 | 1051 | 1504 | 1.431 | 30.08 | 26.5 | 199.655 | |
Trend: | 49.978 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1047 | 344 | 0.329 | 6.88 | 26.0 | -19.634 |
Dimethyl Sulfoxide | 0 | 50 | 1042 | 426 | 0.409 | 8.52 | 26.0 | 0.000 | |
Test Chemical | 1,2-Propylene oxide | 16 | 50 | 1042 | 510 | 0.489 | 10.20 | 26.0 | 19.718 |
50 | 50 | 1036 | 701 | 0.677 | 14.02 | 26.0 | 65.507 | ||
160 | 50 | 1050 | 1228 | 1.170 | 24.56 | 26.0 | 186.067 | ||
500 | 50 | 1035 | 3037 | 2.934 | 60.74 | 26.0 | 617.732 | ||
1000 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.3 | 50 | 1043 | 667 | 0.640 | 13.34 | 26.0 | 56.423 |
Cyclophosphamide | 2 | 10 | 212 | 369 | 1.741 | 36.90 | 26.0 | 325.744 | |
Trend: | 55.148 | ||||||||
Probability: | 0.000 |