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Study Information
Study Attribute Value
CEBS Accession Number: 002-01065-0001-0000-5
Chemical Name: 1,2-Propylene oxide
CASRN: 75-56-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 772114_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/23/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 471 0.449 9.42 26.5 0.000
Negative (Not Specified) 
0         
 50 1047 455 0.435 9.10 26.5 -3.305
Test Chemical 1,2-Propylene oxide 
1.6       
 50 1051 565 0.538 11.30 26.5 19.615 
5         
 50 1044 764 0.732 15.28 26.5 62.830 
16         
 50 1044 1144 1.096 22.88 26.5 143.818 
50         
 50 1046 2677 2.559 53.54 26.5 469.452 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 536 0.512 10.72 26.5 14.018
Mitomycin-C 
 0.01      
 50 1047 2586 2.470 51.72 26.5 449.569
Trend: 47.153        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/06/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 436 0.418 8.72 26.0 -0.398
Dimethyl Sulfoxide 
0         
 50 1046 439 0.420 8.78 26.0 0.000
Test Chemical 1,2-Propylene oxide 
5         
 50 1041 681 0.654 13.62 26.0 55.870 
16         
 50 1041 941 0.904 18.82 26.0 115.380 
50         
 50 1045 2047 1.959 40.94 26.0 366.733 
100         
 50 1048 2533 2.417 50.66 26.0 475.892
Positive Control Mitomycin-C 
 0.001     
 50 1046 1402 1.340 28.04 26.0 219.362
Mitomycin-C 
 0.01      
 10 211 693 3.284 69.30 26.0 682.561
Trend: 47.801        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/11/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 450 0.430 9.00 26.5 -9.914
Dimethyl Sulfoxide 
0         
 50 1047 500 0.478 10.00 26.5 0.000
Test Chemical 1,2-Propylene oxide 
16         
 50 1052 513 0.488 10.26 26.5 2.112 
50         
 50 1043 696 0.667 13.92 26.5 39.734 
160         
 50 1046 1047 1.001 20.94 26.5 109.600 
500         
 50 1044 2881 2.760 57.62 26.5 477.856 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1047 450 0.430 9.00 26.5 -10.000
Cyclophosphamide 
2         
 50 1051 1504 1.431 30.08 26.5 199.655
Trend: 49.978        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/06/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 344 0.329 6.88 26.0 -19.634
Dimethyl Sulfoxide 
0         
 50 1042 426 0.409 8.52 26.0 0.000
Test Chemical 1,2-Propylene oxide 
16         
 50 1042 510 0.489 10.20 26.0 19.718 
50         
 50 1036 701 0.677 14.02 26.0 65.507 
160         
 50 1050 1228 1.170 24.56 26.0 186.067 
500         
 50 1035 3037 2.934 60.74 26.0 617.732 
1000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1043 667 0.640 13.34 26.0 56.423
Cyclophosphamide 
2         
 10 212 369 1.741 36.90 26.0 325.744
Trend: 55.148        
Probability: 0.000