Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01065-0002-0000-6 |
Chemical Name: | 1,2-Propylene oxide |
CASRN: | 75-56-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 772114_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
No Activation | 2 | Weakly Positive* |
Induced Rat Liver S9 | 2_S9 | Weakly Positive* |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 1,2-Propylene oxide | 5 | 100 | 3 | 0.030 | 2.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
16 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
50 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
160 | 100 | 6 | 0.060 | 6.0 | 2 | 0.020 | 2.0 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | ||
500 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.25 | 100 | 24 | 0.240 | 21.0 | 14 | 0.140 | 12.0 | 10 | 0.100 | 8.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 1 | 50 | 19 | 0.380 | 34.0 | 11 | 0.220 | 22.0 | 8 | 0.160 | 16.0 | 0 | 0.000 | 0.0 | |
Trend: | 2.685 | 1.418 | 1.511 | ||||||||||||
Probability: | 0.004 | 0.078 | 0.065 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 100 | 4 | 0.040 | 3.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 1,2-Propylene oxide | 50 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
160 | 100 | 4 | 0.040 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 2.0 | 0 | 0.000 | 0.0 | ||
500 | 100 | 26 | 0.260 | 23.0 | 20 | 0.200 | 17.0 | 6 | 0.060 | 6.0 | 0 | 0.000 | 0.0 | ||
750 | 100 | 90 | 0.900 | 34.0 | 43 | 0.430 | 23.0 | 26 | 0.260 | 18.0 | 21 | 0.210 | 3.0 | ||
1000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 15 | 0.150 | 13.0 | 8 | 0.080 | 7.0 | 6 | 0.060 | 6.0 | 1 | 0.010 | 1.0 |
Cyclophosphamide | 50 | 50 | 25 | 0.500 | 38.0 | 21 | 0.420 | 30.0 | 4 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | |
Trend: | 8.179 | 7.052 | 4.988 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 1,2-Propylene oxide | 16 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
50 | 100 | 8 | 0.080 | 6.0 | 2 | 0.020 | 2.0 | 6 | 0.060 | 5.0 | 0 | 0.000 | 0.0 | ||
160 | 100 | 12 | 0.120 | 9.0 | 6 | 0.060 | 5.0 | 6 | 0.060 | 5.0 | 0 | 0.000 | 0.0 | ||
500 | 100 | 72 | 0.720 | 42.0 | 30 | 0.300 | 22.0 | 42 | 0.420 | 28.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.25 | 100 | 71 | 0.710 | 46.0 | 36 | 0.360 | 28.0 | 35 | 0.350 | 29.0 | 0 | 0.000 | 0.0 |
Trend: | 8.152 | 6.627 | 5.974 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 1,2-Propylene oxide | 160 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
500 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
1600 | 100 | 119 | 1.190 | 40.0 | 42 | 0.420 | 27.0 | 37 | 0.370 | 20.0 | 40 | 0.400 | 4.0 | ||
5000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 39 | 0.390 | 27.0 | 21 | 0.210 | 18.0 | 18 | 0.180 | 15.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 50 | 50 | 19 | 0.380 | 38.0 | 7 | 0.140 | 14.0 | 12 | 0.240 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 7.465 | 6.490 | 4.927 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |