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Study Information
Study Attribute Value
CEBS Accession Number: 002-01065-0002-0000-6
Chemical Name: 1,2-Propylene oxide
CASRN: 75-56-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 772114_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Weakly Positive* 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 04/13/1984    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Propylene oxide 
5         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
16         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
50         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
160         
 100 6 0.060 6.0 2 0.020 2.0 3 0.030 3.0 1 0.010 1.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 24 0.240 21.0 14 0.140 12.0 10 0.100 8.0 0 0.000 0.0
Mitomycin-C 
1         
 50 19 0.380 34.0 11 0.220 22.0 8 0.160 16.0 0 0.000 0.0
Trend: 2.685 1.418 1.511  
Probability: 0.004 0.078 0.065  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/12/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 2.0 0 0.000 0.0
Test Chemical: 1,2-Propylene oxide 
50         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
160         
 100 4 0.040 2.0 0 0.000 0.0 4 0.040 2.0 0 0.000 0.0 
500         
 100 26 0.260 23.0 20 0.200 17.0 6 0.060 6.0 0 0.000 0.0 
750         
 100 90 0.900 34.0 43 0.430 23.0 26 0.260 18.0 21 0.210 3.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 15 0.150 13.0 8 0.080 7.0 6 0.060 6.0 1 0.010 1.0
Cyclophosphamide 
50         
 50 25 0.500 38.0 21 0.420 30.0 4 0.080 8.0 0 0.000 0.0
Trend: 8.179 7.052 4.988  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 01/25/1984    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 1,2-Propylene oxide 
16         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
50         
 100 8 0.080 6.0 2 0.020 2.0 6 0.060 5.0 0 0.000 0.0 
160         
 100 12 0.120 9.0 6 0.060 5.0 6 0.060 5.0 0 0.000 0.0 
500         
 100 72 0.720 42.0 30 0.300 22.0 42 0.420 28.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 71 0.710 46.0 36 0.360 28.0 35 0.350 29.0 0 0.000 0.0
Trend: 8.152 6.627 5.974  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/25/1984    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2-Propylene oxide 
160         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0 
500         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0 
1600         
 100 119 1.190 40.0 42 0.420 27.0 37 0.370 20.0 40 0.400 4.0 
5000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 39 0.390 27.0 21 0.210 18.0 18 0.180 15.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 19 0.380 38.0 7 0.140 14.0 12 0.240 24.0 0 0.000 0.0
Trend: 7.465 6.490 4.927  
Probability: 0.000 0.000 0.000