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Study Information
Study Attribute Value
CEBS Accession Number: 002-01065-0013-0000-8
Chemical Name: 1,2-Propylene oxide
CASRN: 75-56-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 024319
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Fischer Medium 
 0         
 89 100 105 40 31
    104 66 100 32
    100 109 73 24
    104 126 86 27
Test Chemical 1,2-Propylene oxide 
 0.63      
 40 22 287 239 252*
    47 26 374 264
  
1.25      
 66 79 53 27 28
    60 58 51 29
  
2.5       
 80 96 85 35 35
    83 80 84 34
  
5         
 76 102 84 37 33
    70 79 61 29
  
10         
 83 100 111 45 40
    89 99 95 36
  
20         
 92 101 86 31 24
    72 120 35 16
  
30         
   
Positive Control Ethyl Methane Sulfonate 
250         
 65 80 380 194 213*
    60 91 420 232

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Air 
 0         
 115 90 65 19 25
    120 96 90 25
    97 100 81 28
    96 114 85 29
Test Chemical 1,2-Propylene oxide 
 0.04      
 103 74 91 30 27
    102 102 74 24
  
 0.08      
 90 47 76 28 35
    98 71 124 42
  
 0.16      
 77 92 142 61 67*
    75 51 164 73
  
 0.31      
 76 58 308 135 121*
    87 43 279 107
  
 0.63      
 54 15 364 223 166*
    114 50 375 109
  
1.25      
   
Positive Control Methyl Methane Sulfonate 
15         
 31 8 221 235 236*
    28 9 201 238

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Air 
 0         
 101 104 64 21 16
    94 110 38 14
    100 89 47 16
    103 97 40 13
Test Chemical 1,2-Propylene oxide 
 0.04      
 66 76 64 32 29*
    85 81 63 25
  
 0.08      
 78 75 75 32 38*
    81 74 107 44
  
 0.16      
 76 60 149 65 72*
    76 66 178 78
  
 0.31      
 52 29 301 194 160*
    66 35 250 127
  
 0.63      
 42 9 453 360 320*
    47 17 395 280
  
1.25      
   
Positive Control Methyl Methane Sulfonate 
15         
 47 21 240 170 171*
    45 13 229 172

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination