Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01065-0013-0000-8 |
Chemical Name: | 1,2-Propylene oxide |
CASRN: | 75-56-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 024319 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Fischer Medium | 0 | 89 | 100 | 105 | 40 | 31 |
104 | 66 | 100 | 32 | ||||
100 | 109 | 73 | 24 | ||||
104 | 126 | 86 | 27 | ||||
Test Chemical | 1,2-Propylene oxide | 0.63 | 40 | 22 | 287 | 239 | 252* |
47 | 26 | 374 | 264 | ||||
1.25 | 66 | 79 | 53 | 27 | 28 | ||
60 | 58 | 51 | 29 | ||||
2.5 | 80 | 96 | 85 | 35 | 35 | ||
83 | 80 | 84 | 34 | ||||
5 | 76 | 102 | 84 | 37 | 33 | ||
70 | 79 | 61 | 29 | ||||
10 | 83 | 100 | 111 | 45 | 40 | ||
89 | 99 | 95 | 36 | ||||
20 | 92 | 101 | 86 | 31 | 24 | ||
72 | 120 | 35 | 16 | ||||
30 | |||||||
Positive Control | Ethyl Methane Sulfonate | 250 | 65 | 80 | 380 | 194 | 213* |
60 | 91 | 420 | 232 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Air | 0 | 115 | 90 | 65 | 19 | 25 |
120 | 96 | 90 | 25 | ||||
97 | 100 | 81 | 28 | ||||
96 | 114 | 85 | 29 | ||||
Test Chemical | 1,2-Propylene oxide | 0.04 | 103 | 74 | 91 | 30 | 27 |
102 | 102 | 74 | 24 | ||||
0.08 | 90 | 47 | 76 | 28 | 35 | ||
98 | 71 | 124 | 42 | ||||
0.16 | 77 | 92 | 142 | 61 | 67* | ||
75 | 51 | 164 | 73 | ||||
0.31 | 76 | 58 | 308 | 135 | 121* | ||
87 | 43 | 279 | 107 | ||||
0.63 | 54 | 15 | 364 | 223 | 166* | ||
114 | 50 | 375 | 109 | ||||
1.25 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 31 | 8 | 221 | 235 | 236* |
28 | 9 | 201 | 238 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Air | 0 | 101 | 104 | 64 | 21 | 16 |
94 | 110 | 38 | 14 | ||||
100 | 89 | 47 | 16 | ||||
103 | 97 | 40 | 13 | ||||
Test Chemical | 1,2-Propylene oxide | 0.04 | 66 | 76 | 64 | 32 | 29* |
85 | 81 | 63 | 25 | ||||
0.08 | 78 | 75 | 75 | 32 | 38* | ||
81 | 74 | 107 | 44 | ||||
0.16 | 76 | 60 | 149 | 65 | 72* | ||
76 | 66 | 178 | 78 | ||||
0.31 | 52 | 29 | 301 | 194 | 160* | ||
66 | 35 | 250 | 127 | ||||
0.63 | 42 | 9 | 453 | 360 | 320* | ||
47 | 17 | 395 | 280 | ||||
1.25 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 47 | 21 | 240 | 170 | 171* |
45 | 13 | 229 | 172 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination