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Study Information
Study Attribute Value
CEBS Accession Number: 002-01065-0015-0000-0
Chemical Name: 1,2-Propylene oxide
CASRN: 75-56-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 669217_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/22/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0268
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 8.75 ± 2.17 0.0000
Test Chemical 1,2-Propylene oxide 
75         
 8 0.25 ± 0.25 0.8420
  
150         
 8 0.50 ± 0.50 0.6731
  
300         
 8 1.75 ± 0.45 0.1015
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/04/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0087
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 9.75 ± 3.01 0.0000
Test Chemical 1,2-Propylene oxide 
75         
 8 2.00 ± 0.85 0.1223
  
150         
 8 4.75 ± 0.75 0.0008
  
300         
 8 3.50 ± 0.73 0.0086
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/11/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0475
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 14.50 ± 1.76 0.0000
Test Chemical 1,2-Propylene oxide 
75         
 8 1.50 ± 0.63 0.0776
  
150         
 8 1.50 ± 0.33 0.0776
  
300         
 8 2.00 ± 0.65 0.0281
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.50 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/16/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0077
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 22.00 ± 2.20 0.0000
Test Chemical 1,2-Propylene oxide 
75         
 8 1.50 ± 0.98 0.5000
  
150         
 8 1.00 ± 0.53 0.7378
  
300         
 8 3.75 ± 0.96 0.0233
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.73 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed