Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01068-0001-0000-8 |
Chemical Name: | 1,3,5-Triglycidyl isocyanurate |
CASRN: | 2451-62-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 829758_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1046 | 400 | 0.382 | 8.00 | 26.5 | 0.000 |
Test Chemical | 1,3,5-Triglycidyl isocyanurate | 0.066 | 50 | 1038 | 699 | 0.673 | 13.98 | 26.5 | 76.097 |
0.198 | 10 | 209 | 523 | 2.502 | 52.30 | 26.5 | 554.376 | ||
0.66 | 10 | 209 | 870 | 4.163 | 87.00 | 26.5 | 988.541 | ||
1.98 | 0 | 0 | 0 | 0.000 | 0.00 | 26.5 | N/A | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1045 | 565 | 0.541 | 11.30 | 26.5 | 41.385 |
Mitomycin-C | 0.01 | 10 | 207 | 241 | 1.164 | 24.10 | 26.5 | 204.452 | |
Trend: | 50.900 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1047 | 469 | 0.448 | 9.38 | 26.5 | 0.000 |
Test Chemical | 1,3,5-Triglycidyl isocyanurate | 0.101 | 10 | 210 | 390 | 1.857 | 39.00 | 26.5 | 314.590 |
0.303 | 10 | 211 | 757 | 3.588 | 75.70 | 26.5 | 700.917 | ||
0.505 | 10 | 216 | 895 | 4.144 | 89.50 | 26.5 | 825.003 | ||
0.76 | 0 | 0 | 0 | 0.000 | 0.00 | 26.5 | N/A | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1046 | 625 | 0.598 | 12.50 | 26.5 | 33.390 |
Mitomycin-C | 0.01 | 10 | 210 | 319 | 1.519 | 31.90 | 26.5 | 239.114 | |
Trend: | 49.071 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1033 | 450 | 0.436 | 9.00 | 26.0 | 0.000 |
Test Chemical | 1,3,5-Triglycidyl isocyanurate | 1.98 | 50 | 1037 | 989 | 0.954 | 19.78 | 26.0 | 118.930 |
6.6 | 10 | 208 | 329 | 1.582 | 32.90 | 26.0 | 263.095 | ||
19.8 | 10 | 210 | 822 | 3.914 | 82.20 | 26.0 | 798.546 | ||
66 | 0 | 0 | 0 | 0.000 | 0.00 | 26.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.5 | 50 | 1030 | 723 | 0.702 | 14.46 | 26.0 | 61.135 |
Cyclophosphamide | 2.5 | 10 | 207 | 254 | 1.227 | 25.40 | 26.0 | 181.677 | |
Trend: | 42.266 | ||||||||
Probability: | 0.000 |