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Study Information
Study Attribute Value
CEBS Accession Number: 002-01068-0002-0000-9
Chemical Name: 1,3,5-Triglycidyl isocyanurate
CASRN: 2451-62-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 829758_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 05/15/1986    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: 1,3,5-Triglycidyl isocyanurate 
3         
 50 17 0.340 30.0 9 0.180 18.0 7 0.140 14.0 1 0.020 1.0 
10         
 50 70 1.400 72.0 24 0.480 34.0 46 0.920 54.0 0 0.000 0.0 
30         
 15 56 3.733 87.0 7 0.467 33.0 29 1.933 67.0 20 1.333 2.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.75      
 100 52 0.520 33.0 14 0.140 13.0 28 0.280 23.0 10 0.100 1.0
Mitomycin-C 
5         
 50 64 1.280 60.0 19 0.380 30.0 45 0.900 46.0 0 0.000 0.0
Trend: 12.572 7.942 10.598  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/15/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 7 0.035 3.0 3 0.015 1.5 4 0.020 2.0 0 0.000 0.0
Test Chemical: 1,3,5-Triglycidyl isocyanurate 
10         
 200 40 0.200 18.0 9 0.045 4.5 31 0.155 13.5 0 0.000 0.0 
30         
 50 67 1.340 62.0 28 0.560 34.0 29 0.580 38.0 10 0.200 1.0 
100         
 20 118 5.900 85.0 17 0.850 40.0 21 1.050 40.0 80 4.000 8.0
Positive Control: Cyclophosphamide 
50         
 50 60 1.200 46.0 17 0.340 22.0 32 0.640 32.0 11 0.220 2.0
Trend: 11.629 8.178 7.738  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 06/17/1986    Harvest Time: 10 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 2.5 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: 1,3,5-Triglycidyl isocyanurate 
9.95      
 20 80 4.000 80.0 6 0.300 30.0 44 2.200 60.0 30 1.500 3.0 
19.9       
 15 72 4.800 100.0 8 0.533 40.0 34 2.267 80.0 30 2.000 3.0 
29.9       
 10 34 3.400 100.0 6 0.600 50.0 28 2.800 100.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.75      
 50 38 0.760 38.0 6 0.120 10.0 22 0.440 30.0 10 0.200 1.0
Mitomycin-C 
5         
 50 49 0.980 60.0 10 0.200 18.0 38 0.760 50.0 1 0.020 1.0
Trend: 13.073 8.055 12.547  
Probability: 0.000 0.000 0.000