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Study Information
Study Attribute Value
CEBS Accession Number: 002-01069-0001-0000-9
Chemical Name: 1,3,5-tris(2-Hydroxyethyl)triazine-2,4,6-trione
CASRN: 839-90-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 674293_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/23/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 364 0.347 7.28 26.5 0.000
Test Chemical 1,3,5-tris(2-Hydroxyethyl)triazine-2,4,6-trione 
386         
 50 1046 369 0.353 7.38 26.5 1.567 
1160         
 50 1050 379 0.361 7.58 26.5 3.923 
3860         
 50 1046 353 0.337 7.06 26.5 -2.837
Positive Control Mitomycin-C 
 0.0015    
 50 1049 568 0.541 11.36 26.5 55.895
Mitomycin-C 
 0.01      
 10 208 266 1.279 26.60 26.5 268.195
Trend: -0.274        
Probability: 0.608        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/23/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 453 0.434 9.06 26.0 0.000
Test Chemical 1,3,5-tris(2-Hydroxyethyl)triazine-2,4,6-trione 
386         
 50 1047 441 0.421 8.82 26.0 -2.928 
1160         
 50 1049 439 0.418 8.78 26.0 -3.552 
3860         
 50 1049 397 0.378 7.94 26.0 -12.780
Positive Control Cyclophosphamide 
 0.4       
 50 1038 673 0.648 13.46 26.0 49.424
Cyclophosphamide 
2.5       
 10 210 348 1.657 34.80 26.0 281.911
Trend: -1.918        
Probability: 0.972