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Study Information
Study Attribute Value
CEBS Accession Number: 002-01069-0002-0000-0
Chemical Name: 1,3,5-tris(2-Hydroxyethyl)triazine-2,4,6-trione
CASRN: 839-90-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 674293_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/06/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 1,3,5-tris(2-Hydroxyethyl)triazine-2,4,6-trione 
402         
 200 14 0.070 6.5 2 0.010 1.0 12 0.060 5.5 0 0.000 0.0 
1210         
 200 16 0.080 7.5 6 0.030 3.0 10 0.050 4.5 0 0.000 0.0 
4020         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 30 0.150 13.0 5 0.025 2.5 25 0.125 11.0 0 0.000 0.0
Mitomycin-C 
5         
 50 12 0.240 20.0 2 0.040 4.0 10 0.200 18.0 0 0.000 0.0
Trend: -0.113 -0.329 0.071  
Probability: 0.545 0.629 0.472  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/13/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,3,5-tris(2-Hydroxyethyl)triazine-2,4,6-trione 
381         
 200 5 0.025 2.0 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0 
1140         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
2290         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
3810         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 32 0.640 24.0 3 0.060 6.0 9 0.180 16.0 20 0.400 2.0
Trend: 0.190 -0.783 0.499  
Probability: 0.425 0.783 0.309