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Study Information
Study Attribute Value
CEBS Accession Number: 002-01070-0013-0000-4
Chemical Name: 1,3-Butadiene
CASRN: 106-99-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A93093_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/06/86 24 Mouse Male Bone Marrow Inhalation x 1/study, 24 hour 0.0000
Test Group Dose
(ppm)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Test Chemical 1,3-Butadiene 
6.25      
 11 1.64 ± 0.36 0.8005
  
62.5       
 9 3.33 ± 1.25 0.1639
  
625         
 12 14.00 ± 3.18 0.0000
Vehicle Control No Stressor 
 0         
 12 2.33 ± 0.85 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed