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Study Information
Study Attribute Value
CEBS Accession Number: 002-01076-0001-0000-7
Chemical Name: 1,3-Dichloropropene (Telone II)
CASRN: 542-75-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 129307_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/20/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 400 0.382 8.00 30.5 0.000
Test Chemical 1,3-Dichloropropene (Telone II) 
 0.995     
 50 1036 392 0.378 7.84 30.5 -1.054 
9.95      
 50 1048 478 0.456 9.56 30.5 19.272 
29.9       
 50 1048 680 0.649 13.60 30.5 69.676
Positive Control Mitomycin-C 
 0.0015    
 50 1047 601 0.574 12.02 30.5 50.106
Mitomycin-C 
 0.01      
 10 209 348 1.665 34.80 30.5 335.416
Trend: 8.819        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/05/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 385 0.368 7.70 26.5 0.000
Test Chemical 1,3-Dichloropropene (Telone II) 
30         
 50 1048 666 0.635 13.32 26.0 72.492 
40         
 50 1055 856 0.811 17.12 26.0 120.230 
50         
 50 1051 985 0.937 19.70 30.5 154.384
Positive Control Mitomycin-C 
 0.0015    
 50 1045 565 0.541 11.30 26.5 46.753
Mitomycin-C 
 0.01      
 10 210 299 1.424 29.90 26.5 286.463
Trend: 16.462        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/20/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 385 0.368 7.70 25.5 0.000
Test Chemical 1,3-Dichloropropene (Telone II) 
2.99      
 50 1041 392 0.377 7.84 25.5 2.307 
9.95      
 50 1041 500 0.480 10.00 25.5 30.494 
29.9       
 50 1051 660 0.628 13.20 25.5 70.613
Positive Control Cyclophosphamide 
 0.5       
 50 1050 750 0.714 15.00 25.5 94.063
Cyclophosphamide 
2.5       
 10 207 358 1.729 35.80 25.5 369.876
Trend: 9.370        
Probability: 0.000