Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01076-0001-0000-7 |
Chemical Name: | 1,3-Dichloropropene (Telone II) |
CASRN: | 542-75-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 129307_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1046 | 400 | 0.382 | 8.00 | 30.5 | 0.000 |
Test Chemical | 1,3-Dichloropropene (Telone II) | 0.995 | 50 | 1036 | 392 | 0.378 | 7.84 | 30.5 | -1.054 |
9.95 | 50 | 1048 | 478 | 0.456 | 9.56 | 30.5 | 19.272 | ||
29.9 | 50 | 1048 | 680 | 0.649 | 13.60 | 30.5 | 69.676 | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1047 | 601 | 0.574 | 12.02 | 30.5 | 50.106 |
Mitomycin-C | 0.01 | 10 | 209 | 348 | 1.665 | 34.80 | 30.5 | 335.416 | |
Trend: | 8.819 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1045 | 385 | 0.368 | 7.70 | 26.5 | 0.000 |
Test Chemical | 1,3-Dichloropropene (Telone II) | 30 | 50 | 1048 | 666 | 0.635 | 13.32 | 26.0 | 72.492 |
40 | 50 | 1055 | 856 | 0.811 | 17.12 | 26.0 | 120.230 | ||
50 | 50 | 1051 | 985 | 0.937 | 19.70 | 30.5 | 154.384 | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1045 | 565 | 0.541 | 11.30 | 26.5 | 46.753 |
Mitomycin-C | 0.01 | 10 | 210 | 299 | 1.424 | 29.90 | 26.5 | 286.463 | |
Trend: | 16.462 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1046 | 385 | 0.368 | 7.70 | 25.5 | 0.000 |
Test Chemical | 1,3-Dichloropropene (Telone II) | 2.99 | 50 | 1041 | 392 | 0.377 | 7.84 | 25.5 | 2.307 |
9.95 | 50 | 1041 | 500 | 0.480 | 10.00 | 25.5 | 30.494 | ||
29.9 | 50 | 1051 | 660 | 0.628 | 13.20 | 25.5 | 70.613 | ||
Positive Control | Cyclophosphamide | 0.5 | 50 | 1050 | 750 | 0.714 | 15.00 | 25.5 | 94.063 |
Cyclophosphamide | 2.5 | 10 | 207 | 358 | 1.729 | 35.80 | 25.5 | 369.876 | |
Trend: | 9.370 | ||||||||
Probability: | 0.000 |