COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01076-0002-0000-8
Chemical Name: 1,3-Dichloropropene (Telone II)
CASRN: 542-75-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 129307_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Test Failure 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 
No Activation  3  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 03/07/1985    Harvest Time: 10.5 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 1,3-Dichloropropene (Telone II) 
10         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
30         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
49.9       
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
5         
 50 1 0.020 2.0 0 0.000 0.0 1 0.020 2.0 0 0.000 0.0
Mitomycin-C 
5         
 50 3 0.060 6.0 0 0.000 0.0 3 0.060 6.0 0 0.000 0.0
Trend: 0.692 -0.111 0.280  
Probability: 0.244 0.544 0.390  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/11/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,3-Dichloropropene (Telone II) 
10         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
30         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
50         
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 26 0.520 36.0 20 0.400 32.0 6 0.120 12.0 0 0.000 0.0
Trend: 1.594 1.104 1.172  
Probability: 0.055 0.135 0.121  


Trial #:2   Activation: No Activation    Date: 04/11/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 7 0.070 6.0 0 0.000 0.0 6 0.060 5.0 1 0.010 1.0
Test Chemical: 1,3-Dichloropropene (Telone II) 
50         
 100 7 0.070 7.0 0 0.000 0.0 7 0.070 7.0 0 0.000 0.0 
75         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0 
100         
 100 8 0.080 6.0 0 0.000 0.0 7 0.070 6.0 1 0.010 1.0
Positive Control: Mitomycin-C 
5         
 50 28 0.560 40.0 12 0.240 18.0 16 0.320 24.0 0 0.000 0.0
Trend: -0.098 0.000 0.185  
Probability: 0.539 0.000 0.427  


Trial #:3   Activation: No Activation    Date: 03/28/1985    Harvest Time: 10 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: 1,3-Dichloropropene (Telone II) 
4.91      
 100 5 0.050 3.0 0 0.000 0.0 5 0.050 3.0 0 0.000 0.0 
9.8       
 100 9 0.090 9.0 1 0.010 1.0 8 0.080 8.0 0 0.000 0.0 
29.5       
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
49.1       
 100 24 0.240 16.0 1 0.010 1.0 21 0.210 16.0 2 0.020 2.0
Positive Control: Mitomycin-C 
5         
 50 52 1.040 50.0 14 0.280 18.0 28 0.560 42.0 10 0.200 1.0
Trend: 2.560 0.871 2.614  
Probability: 0.005 0.192 0.004