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Study Information
Study Attribute Value
CEBS Accession Number: 002-01076-0012-0000-9
Chemical Name: 1,3-Dichloropropene (Telone II)
CASRN: 542-75-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 725960
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 99 94 85 29 29
    84 98 72 29
    94 109 80 28
    103 99 87 28
Test Chemical 1,3-Dichloropropene (Telone II) 
2.5       
 81 60 130 53 42*
    92 76 116 42
    111 81 105 32
  
5         
 87 50 179 68 66*
    85 55 163 64
    68 61 132 65
  
10         
 70 31 285 136 173*
    53 23 339 213
    69 29 355 171
  
20         
 21r 1 287 467 295*
    68 9 502 248
    33 4 334 343
  
30         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 53 37 556 350 367*
    63 40 686 361
    38 26 441 390

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 96 112 99 35 32
    95 95 104 37
    83 105 56 23
    71 88 75 35
Test Chemical 1,3-Dichloropropene (Telone II) 
2.5       
 67 49 200 99 83*
    118 82 228 64
    102 60 258 84
  
5         
 61 26 193 105 128*
    96 44 371 129
    77 28 343 149
  
10         
 46 10 314 228 261*
    33 5 341 343
    47 11 302 213
  
15         
   
  
20         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 74 80 274 124 123*
    73 52 220 101
    65 62 281 143

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination