Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01076-0012-0000-9 |
Chemical Name: | 1,3-Dichloropropene (Telone II) |
CASRN: | 542-75-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 725960 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 99 | 94 | 85 | 29 | 29 |
84 | 98 | 72 | 29 | ||||
94 | 109 | 80 | 28 | ||||
103 | 99 | 87 | 28 | ||||
Test Chemical | 1,3-Dichloropropene (Telone II) | 2.5 | 81 | 60 | 130 | 53 | 42* |
92 | 76 | 116 | 42 | ||||
111 | 81 | 105 | 32 | ||||
5 | 87 | 50 | 179 | 68 | 66* | ||
85 | 55 | 163 | 64 | ||||
68 | 61 | 132 | 65 | ||||
10 | 70 | 31 | 285 | 136 | 173* | ||
53 | 23 | 339 | 213 | ||||
69 | 29 | 355 | 171 | ||||
20 | 21r | 1 | 287 | 467 | 295* | ||
68 | 9 | 502 | 248 | ||||
33 | 4 | 334 | 343 | ||||
30 | |||||||
Positive Control | Methyl Methane Sulfonate | 5 | 53 | 37 | 556 | 350 | 367* |
63 | 40 | 686 | 361 | ||||
38 | 26 | 441 | 390 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 96 | 112 | 99 | 35 | 32 |
95 | 95 | 104 | 37 | ||||
83 | 105 | 56 | 23 | ||||
71 | 88 | 75 | 35 | ||||
Test Chemical | 1,3-Dichloropropene (Telone II) | 2.5 | 67 | 49 | 200 | 99 | 83* |
118 | 82 | 228 | 64 | ||||
102 | 60 | 258 | 84 | ||||
5 | 61 | 26 | 193 | 105 | 128* | ||
96 | 44 | 371 | 129 | ||||
77 | 28 | 343 | 149 | ||||
10 | 46 | 10 | 314 | 228 | 261* | ||
33 | 5 | 341 | 343 | ||||
47 | 11 | 302 | 213 | ||||
15 | |||||||
20 | |||||||
Positive Control | Methyl Methane Sulfonate | 5 | 74 | 80 | 274 | 124 | 123* |
73 | 52 | 220 | 101 | ||||
65 | 62 | 281 | 143 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination