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Study Information
Study Attribute Value
CEBS Accession Number: 002-01076-0014-0000-1
Chemical Name: 1,3-Dichloropropene (Telone II)
CASRN: 542-75-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 208737_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/03/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0001
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 14.50 ± 2.16 0.0000
Test Chemical 1,3-Dichloropropene (Telone II) 
50         
 8 1.25 ± 0.53 0.7992
  
100         
 8 3.25 ± 0.37 0.1344
  
200         
 8 5.75 ± 1.10 0.0030
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.65 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/16/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0100
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 6.00 ± 1.69 0.0004
Test Chemical 1,3-Dichloropropene (Telone II) 
200         
 8 4.25 ± 0.70 0.0100
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.63 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed