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Study Information
Study Attribute Value
CEBS Accession Number: 002-01083-0001-0000-5
Chemical Name: 1,3-Dioxane
CASRN: 505-22-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 183082_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/12/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1038 412 0.397 8.24 25.5 0.000
Test Chemical 1,3-Dioxane 
350         
 50 1039 377 0.363 7.54 25.5 -8.583 
1040         
 50 1048 428 0.408 8.56 25.5 2.892 
3480         
 50 1037 849 0.819 16.98 33.5 106.267
Positive Control Triethylenemelamine 
 0.015     
 50 1049 3258 3.106 65.16 25.5 682.484
Trend: 13.549        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/03/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1040 417 0.401 8.34 25.8 0.000
Test Chemical 1,3-Dioxane 
2080         
 50 1044 670 0.642 13.40 25.8 60.056 
2780         
 50 1049 707 0.674 14.14 29.8 68.090 
3130         
 50 1037 672 0.648 13.44 29.8 61.617
Positive Control Triethylenemelamine 
 0.015     
 50 1042 3510 3.369 70.20 25.8 740.111
Trend: 7.504        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/12/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1038 424 0.408 8.48 26.0 0.000
Test Chemical 1,3-Dioxane 
348         
 50 1032 453 0.439 9.06 26.0 7.461 
1040         
 50 1007 442 0.439 8.84 26.0 7.454 
3480         
 50 1029 575 0.559 11.50 26.0 36.799 
10450         
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1031 1580 1.532 31.60 26.0 275.172
Trend: 4.826        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/03/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 452 0.431 9.04 25.8 0.000
Test Chemical 1,3-Dioxane 
5020         
 50 1031 756 0.733 15.12 25.8 70.177 
7520         
 50 1029 907 0.881 18.14 29.8 104.564 
8360         
 50 1047 941 0.899 18.82 29.8 108.584
Positive Control Cyclophosphamide 
1.5       
 50 1032 1527 1.480 30.54 25.8 243.397
Trend: 13.438        
Probability: 0.000