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Study Information
Study Attribute Value
CEBS Accession Number: 002-01083-0002-0000-6
Chemical Name: 1,3-Dioxane
CASRN: 505-22-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 183082_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 08/03/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
Water 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 1,3-Dioxane 
1500         
 100 8 0.080 8.0 5 0.050 5.0 2 0.020 2.0 1 0.010 1.0 
2000         
 100 3 0.030 3.0 0 0.000 0.0 2 0.020 2.0 1 0.010 1.0 
3760         
 100 4 0.040 4.0 0 0.000 0.0 3 0.030 3.0 1 0.010 1.0
Positive Control: Triethylenemelamine 
 0.5       
 100 23 0.230 16.0 6 0.060 6.0 16 0.160 13.0 1 0.010 1.0
Triethylenemelamine 
 0.75      
 25 71 2.840 84.0 14 0.560 48.0 37 1.480 72.0 20 0.800 8.0
Trend: -0.097 -1.301 0.494  
Probability: 0.539 0.903 0.311  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/03/1981    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Water 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,3-Dioxane 
5020         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
7520         
 100 31 0.310 23.0 15 0.150 14.0 15 0.150 15.0 1 0.010 1.0 
8360         
 100 20 0.200 19.0 12 0.120 11.0 7 0.070 7.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
25         
 100 22 0.220 20.0 19 0.190 18.0 3 0.030 3.0 0 0.000 0.0
Trend: 5.671 4.069 4.072  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 07/15/1981    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 7 0.070 6.0 1 0.010 1.0 6 0.060 5.0 0 0.000 0.0
Test Chemical: 1,3-Dioxane 
650         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
1310         
 100 19 0.190 12.0 12 0.120 7.0 7 0.070 6.0 0 0.000 0.0 
2610         
 100 11 0.110 9.0 3 0.030 3.0 8 0.080 6.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.5       
 100 27 0.270 25.0 10 0.100 10.0 16 0.160 15.0 1 0.010 1.0
Trend: 3.208 2.059 2.436  
Probability: 0.001 0.020 0.007