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Study Information
Study Attribute Value
CEBS Accession Number: 002-01086-0002-0000-9
Chemical Name: 1,3-Propylene oxide
CASRN: 503-30-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 377042_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/06/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2837
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 15.25 ± 2.67 0.0000
Test Chemical 1,3-Propylene oxide 
1250         
 8 2.25 ± 0.45 0.8549
  
2500         
 8 3.50 ± 1.35 0.5000
  
5000         
 8 3.75 ± 1.28 0.4250
Vehicle Control No Stressor 
 0         
 8 3.50 ± 0.82 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/26/91 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.8970
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 20.50 ± 3.25 0.0000
Test Chemical 1,3-Propylene oxide 
1050         
 8 1.50 ± 0.50 0.9936
  
2100         
 8 3.25 ± 0.75 0.8202
  
4200         
 8 2.25 ± 0.96 0.9610
Vehicle Control No Stressor 
 0         
 8 4.50 ± 1.30 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed