COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01091-0001-0000-4
Chemical Name: 1,4-Dichlorobenzene (p-dichlorobenzene)
CASRN: 106-46-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 983738_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/13/1982    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 396 0.380 7.92 25.5 0.000
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
167         
 50 1046 430 0.411 8.60 25.5 8.171
Positive Control Mitomycin-C 
 0.005     
 50 518 685 1.322 13.70 25.5 247.963
Trend: 0.000        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/24/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 403 0.391 8.06 25.5 0.000
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
75         
 50 1030 438 0.425 8.76 25.5 8.685 
100         
 50 1019 391 0.384 7.82 25.5 -1.930 
125         
 50 1011 420 0.415 8.40 25.5 6.177 
150         
 50 1024 429 0.419 8.58 25.5 7.075 
200         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 518 621 1.199 24.84 25.5 206.404
Trend: 0.651        
Probability: 0.257        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/10/1982    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 444 0.427 8.88 25.5 0.000
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
75         
 50 1034 536 0.518 10.72 25.5 21.538 
100         
 50 1032 479 0.464 9.58 25.5 8.824 
125         
 50 1010 498 0.493 9.96 25.5 15.605 
150         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 512 705 1.377 28.20 25.5 222.840
Trend: 1.413        
Probability: 0.079        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/24/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1034 408 0.395 8.16 25.5 0.000
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
100         
 50 1027 384 0.374 7.68 25.5 -5.241 
125         
 50 1037 438 0.422 8.76 25.5 7.042 
150         
 50 1023 362 0.354 7.24 25.5 -10.320 
200         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 528 748 1.417 29.92 25.5 259.028
Trend: -0.745        
Probability: 0.772