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Study Information
Study Attribute Value
CEBS Accession Number: 002-01091-0002-0000-5
Chemical Name: 1,4-Dichlorobenzene (p-dichlorobenzene)
CASRN: 106-46-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 983738_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 07/09/1982    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,4-Dichlorobenzene (p-dichlorobenzene) 
50         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
100         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
150         
 100 7 0.070 5.0 1 0.010 1.0 5 0.050 3.0 1 0.010 1.0 
200         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 50 17 0.340 18.0 3 0.060 6.0 14 0.280 12.0 0 0.000 0.0
Trend: 1.395 0.319 1.044  
Probability: 0.081 0.375 0.148  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/14/1982    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 1,4-Dichlorobenzene (p-dichlorobenzene) 
25         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0 
50         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
100         
 100 5 0.050 3.0 1 0.010 1.0 4 0.040 3.0 0 0.000 0.0 
150         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 50 14 0.280 22.0 7 0.140 14.0 6 0.120 8.0 1 0.020 1.0
Trend: -0.525 0.046 -0.525  
Probability: 0.700 0.482 0.700