Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01091-0010-0000-4 |
Chemical Name: | 1,4-Dichlorobenzene (p-dichlorobenzene) |
CASRN: | 106-46-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 465704 |
Study Result: | Equivocal |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 73 | 118 | 82 | 37 | 34 |
70 | 91 | 71 | 34 | ||||
83 | 101 | 98 | 39 | ||||
84 | 91 | 62 | 25 | ||||
Test Chemical | 1,4-Dichlorobenzene (p-dichlorobenzene) | 6.25 | 82 | 91 | 90 | 36 | 44 |
77 | 108 | 118 | 51 | ||||
12.5 | 77 | 82 | 153 | 67 | 62* | ||
81 | 89 | 140 | 58 | ||||
25 | 71 | 75 | 80 | 37 | 42 | ||
88 | 86 | 122 | 46 | ||||
50 | 79 | 53 | 96 | 41 | 42 | ||
95 | 50 | 126 | 44 | ||||
100 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 45 | 32 | 342 | 255 | 286* |
37 | 31 | 347 | 317 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 83 | 97 | 88 | 35 | 38 |
91 | 115 | 108 | 40 | ||||
99 | 95 | 97 | 33 | ||||
80# | 93 | 109 | 46 | ||||
Test Chemical | 1,4-Dichlorobenzene (p-dichlorobenzene) | 30 | 87 | 72 | 107 | 41 | 37 |
86 | 84 | 83 | 32 | ||||
40 | 94 | 60 | 158 | 56 | |||
127r | 71 | 139 | 36 | ||||
50 | 110 | 59 | 138 | 42 | |||
133r | 60 | 132 | 33 | ||||
60 | 112 | 41 | 163 | 49 | 46 | ||
98 | 43 | 128 | 43 | ||||
70 | 102 | 18 | 250 | 82 | 90* | ||
85 | 10 | 248 | 97 | ||||
80 | |||||||
106 | 20 | 226 | 71 | ||||
90 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 42 | 24 | 486 | 386 | 364* |
44 | 21 | 456 | 343 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 86 | 96 | 119 | 46 | 40 |
77 | 100 | 92 | 40 | ||||
93 | 99 | 105 | 38 | ||||
85 | 104 | 93 | 36 | ||||
Test Chemical | 1,4-Dichlorobenzene (p-dichlorobenzene) | 70 | 67 | 79 | 96 | 48 | 43 |
73 | 82 | 84 | 39 | ||||
75 | 90 | 63 | 119 | 44 | 39 | ||
80 | 54 | 82 | 34 | ||||
80 | 61 | 60 | 88 | 48 | 43 | ||
62 | 63 | 71 | 38 | ||||
85 | 69 | 39 | 74 | 36 | 37 | ||
85 | 76 | 97 | 38 | ||||
90 | 75 | 57 | 72 | 32 | 33 | ||
90 | 48 | 93 | 35 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 24 | 20 | 191 | 269 | 245* |
27 | 20 | 178 | 221 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 75 | 97 | 73 | 33 | 36 |
88 | 101 | 77 | 29 | ||||
88 | 100 | 113 | 43 | ||||
79 | 102 | 90 | 38 | ||||
Test Chemical | 1,4-Dichlorobenzene (p-dichlorobenzene) | 55 | 89 | 80 | 107 | 40 | 40 |
95 | 82 | 115 | 40 | ||||
65 | 67 | 77 | 66 | 33 | 36 | ||
73 | 81 | 86 | 39 | ||||
75 | 66 | 67 | 83 | 42 | |||
85 | 87 | 49 | 123 | 47 | 43 | ||
73 | 47 | 83 | 38 | ||||
95 | 76 | 16 | 144 | 63 | 53 | ||
86 | 15 | 109 | 42 | ||||
105 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 26 | 23 | 315 | 406 | 362* |
25 | 29 | 236 | 317 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 73 | 105 | 154 | 71 | 69 |
67 | 87 | 167 | 83 | ||||
91 | 88 | 148 | 54 | ||||
76 | 121 | 159 | 70 | ||||
Test Chemical | 1,4-Dichlorobenzene (p-dichlorobenzene) | 60 | 79 | 59 | 187 | 79 | 81 |
72 | 64 | 180 | 84 | ||||
70 | 80 | 61 | 187 | 78 | 76 | ||
58 | 46 | 129 | 74 | ||||
80 | 61 | 38 | 177 | 96 | 98 | ||
46 | 39 | 136 | 99 | ||||
90 | 47 | 21 | 115 | 82 | 87 | ||
54 | 21 | 147 | 91 | ||||
100 | 79 | 21 | 218 | 92 | 88 | ||
58 | 18 | 147 | 84 | ||||
110 | |||||||
Positive Control | 3-Methylcholanthrene | 2.5 | 66 | 50 | 561 | 285 | 293* |
67 | 64 | 598 | 300 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 70 | 96 | 86 | 41 | 35 |
68 | 89 | 73 | 36 | ||||
86 | 117 | 67 | 26 | ||||
63# | 98 | 67 | 35 | ||||
Test Chemical | 1,4-Dichlorobenzene (p-dichlorobenzene) | 55 | 69 | 55 | 67 | 32 | 33 |
67 | 51 | 67 | 33 | ||||
65 | 55 | 39 | 78 | 48 | 56* | ||
58 | 35 | 112 | 64 | ||||
75 | 62 | 28 | 85 | 46 | 44 | ||
57 | 30 | 74 | 43 | ||||
85 | 70 | 23 | 83 | 40 | 41 | ||
73 | 21 | 92 | 42 | ||||
95 | 64 | 12 | 140 | 73 | 88* | ||
50 | 10 | 155 | 104 | ||||
105 | |||||||
Positive Control | 3-Methylcholanthrene | 2.5 | 41 | 33 | 466 | 384 | 363* |
48 | 33 | 498 | 343 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 88 | 97 | 188 | 72 | 73 |
81 | 100 | 175 | 72 | ||||
67# | 103 | 161 | 80 | ||||
80# | 100 | 166.5 | 70 | ||||
Test Chemical | 1,4-Dichlorobenzene (p-dichlorobenzene) | 80 | 69# | 42 | 211.5 | 102 | 96 |
69 | 46 | 188 | 91 | ||||
85 | 73# | 27 | 247 | 112 | 108 | ||
69 | 26 | 214 | 104 | ||||
90 | 95# | 37 | 175.5 | 62 | 87 | ||
92# | 26 | 306 | 111 | ||||
95 | 87# | 27 | 241.5 | 92 | 100 | ||
67 | 19 | 217 | 108 | ||||
100 | 58 | 19 | 229 | 133 | 119* | ||
77 | 17 | 245 | 106 | ||||
105 | |||||||
Positive Control | 3-Methylcholanthrene | 2.5 | 71 | 64 | 652 | 308 | 356* |
52 | 44 | 627 | 405 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination