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Study Information
Study Attribute Value
CEBS Accession Number: 002-01091-0011-0000-5
Chemical Name: 1,4-Dichlorobenzene (p-dichlorobenzene)
CASRN: 106-46-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 576715_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/18/90 17 Mouse Male Bone Marrow Gavage x 1/study, 17 hour 0.2730
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 8.50 ± 0.73 0.0000
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
750         
 8 1.25 ± 0.37 0.7992
  
1500         
 8 2.50 ± 0.33 0.3168
  
3000         
 8 2.25 ± 0.70 0.4032
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.65 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/18/90 36 Mouse Male Bone Marrow Gavage x 1/study, 36 hour 0.6998
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 7.50 ± 1.59 0.0000
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
750         
 8 1.25 ± 0.53 0.5000
  
1500         
 8 1.25 ± 0.53 0.5000
  
3000         
 7 0.86 ± 0.40 0.6993
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.65 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed