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Study Information
Study Attribute Value
CEBS Accession Number: 002-01093-0001-0000-6
Chemical Name: 1,4-Dioxane
CASRN: 123-91-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 950869_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/25/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1038 412 0.397 8.24 26.0 0.000
Test Chemical 1,4-Dioxane 
1050         
 50 1042 461 0.442 9.22 26.0 11.464 
3500         
 50 1029 465 0.452 9.30 26.0 13.851 
10520         
 50 1042 527 0.506 10.54 26.0 27.422
Positive Control Triethylenemelamine 
 0.015     
 50 1037 2784 2.685 55.68 26.0 576.380
Trend: 3.602        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/25/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1043 492 0.472 9.84 26.0 0.000
Test Chemical 1,4-Dioxane 
1050         
 50 1030 462 0.449 9.24 26.0 -4.912 
3500         
 50 1050 499 0.475 9.98 26.0 0.747 
10520         
 50 1030 430 0.417 8.60 26.0 -11.499
Positive Control Cyclophosphamide 
2         
 50 1045 1429 1.367 28.58 26.0 189.891
Trend: -1.420        
Probability: 0.922