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Study Information
Study Attribute Value
CEBS Accession Number: 002-01095-0001-0000-8
Chemical Name: 1,5-Dinitronaphthalene
CASRN: 605-71-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 730559_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/25/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 515 0.492 10.30 25.5 0.000
Test Chemical 1,5-Dinitronaphthalene 
10         
 50 1038 478 0.461 9.56 25.5 -6.380 
50         
 50 1040 549 0.528 10.98 32.3 7.319 
100         
 50 1044 490 0.469 9.80 32.3 -4.581 
150         
 25 521 267 0.512 10.68 32.3 4.187 
200         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1045 841 0.805 16.82 25.5 63.614
Mitomycin-C 
 0.01      
 5 105 277 2.638 55.40 25.5 436.327
Trend: 0.692        
Probability: 0.245        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/25/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 479 0.460 9.58 25.5 0.000
Test Chemical 1,5-Dinitronaphthalene 
100         
 50 1037 557 0.537 11.14 25.5 16.732 
150         
 50 1046 538 0.514 10.76 25.5 11.780 
200         
 50 1040 530 0.510 10.60 25.5 10.754
Positive Control Cyclophosphamide 
 0.4       
 50 1048 688 0.656 13.76 25.5 42.673
Cyclophosphamide 
2         
 5 105 160 1.524 32.00 25.5 231.166
Trend: 1.284        
Probability: 0.100