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Study Information
Study Attribute Value
CEBS Accession Number: 002-01095-0002-0000-9
Chemical Name: 1,5-Dinitronaphthalene
CASRN: 605-71-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 730559_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Negative 
No Activation  3  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 03/06/1984    Harvest Time: 22 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 10 0.100 4.0 1 0.010 1.0 7 0.070 2.0 2 0.020 2.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 1 0.010 1.0 2 0.020 2.0
Test Chemical: 1,5-Dinitronaphthalene 
150         
 100 26 0.260 15.0 1 0.010 1.0 24 0.240 14.0 1 0.010 1.0 
175         
 100 12 0.120 8.0 4 0.040 4.0 7 0.070 5.0 0 0.000 0.0 
200         
 100 15 0.150 11.0 0 0.000 0.0 13 0.130 9.0 2 0.020 2.0
Positive Control: Mitomycin-C 
 0.035     
 100 12 0.120 10.0 8 0.080 7.0 4 0.040 4.0 0 0.000 0.0
Mitomycin-C 
 0.063     
 25 13 0.520 36.0 7 0.280 28.0 6 0.240 24.0 0 0.000 0.0
Trend: 1.288 0.678 1.256  
Probability: 0.099 0.249 0.105  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/06/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 2 0.020 2.0 1 0.010 1.0
Test Chemical: 1,5-Dinitronaphthalene 
10         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
175         
 200 15 0.075 4.5 1 0.005 0.5 10 0.050 2.0 4 0.020 2.0 
200         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 100 9 0.090 7.0 1 0.010 1.0 7 0.070 5.0 1 0.010 1.0
Cyclophosphamide 
20         
 50 9 0.180 18.0 2 0.040 4.0 5 0.100 10.0 2 0.040 4.0
Trend: 0.591 0.766 -0.021  
Probability: 0.277 0.222 0.508  


Trial #:2   Activation: No Activation    Date: 02/16/1984    Harvest Time: 22.2 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 3.0 3 0.030 3.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 21 0.210 11.0 3 0.030 3.0 18 0.180 10.0 0 0.000 0.0
Test Chemical: 1,5-Dinitronaphthalene 
150         
 100 9 0.090 5.0 3 0.030 2.0 6 0.060 4.0 0 0.000 0.0 
175         
 100 7 0.070 4.0 0 0.000 0.0 6 0.060 3.0 1 0.010 1.0 
200         
 100 7 0.070 6.0 2 0.020 2.0 3 0.030 2.0 2 0.020 2.0
Positive Control: Mitomycin-C 
 0.025     
 100 7 0.070 7.0 3 0.030 3.0 4 0.040 4.0 0 0.000 0.0
Mitomycin-C 
 0.065     
 50 12 0.240 18.0 8 0.160 14.0 4 0.080 8.0 0 0.000 0.0
Trend: -1.473 -0.889 -2.635  
Probability: 0.930 0.813 0.996  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/17/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 18 0.180 14.0 8 0.080 7.0 9 0.090 8.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 37 0.370 22.0 16 0.160 13.0 10 0.100 9.0 11 0.110 2.0
Test Chemical: 1,5-Dinitronaphthalene 
10         
 100 46 0.460 30.0 32 0.320 22.0 13 0.130 11.0 1 0.010 1.0 
150         
 100 14 0.140 9.0 8 0.080 7.0 6 0.060 4.0 0 0.000 0.0 
200         
 100 10 0.100 8.0 6 0.060 4.0 3 0.030 3.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
5         
 100 15 0.150 14.0 8 0.080 8.0 6 0.060 5.0 1 0.010 1.0
Cyclophosphamide 
20         
 25 16 0.640 52.0 8 0.320 8.0 8 0.320 7.0 0 0.000 0.0
Trend: -4.025 -3.077 -2.338  
Probability: 1.000 0.999 0.990  


Trial #:3   Activation: No Activation    Date: 01/18/1984    Harvest Time: 22 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 9 0.090 8.0 1 0.010 1.0 7 0.070 6.0 1 0.010 1.0
Test Chemical: 1,5-Dinitronaphthalene 
25         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
150         
 100 21 0.210 13.0 7 0.070 6.0 13 0.130 9.0 1 0.010 1.0 
200         
 100 23 0.230 18.0 1 0.010 1.0 22 0.220 17.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.025     
 100 10 0.100 9.0 4 0.040 4.0 6 0.060 5.0 0 0.000 0.0
Mitomycin-C 
 0.063     
 25 9 0.360 34.0 5 0.200 20.0 4 0.160 16.0 0 0.000 0.0
Trend: 3.123 1.421 3.238  
Probability: 0.001 0.078 0.001