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Study Information
Study Attribute Value
CEBS Accession Number: 002-01096-0001-0000-9
Chemical Name: 1,5-Naphthalenediamine
CASRN: 2243-62-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 531218_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/01/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 375 0.364 7.50 25.8 0.000
Test Chemical 1,5-Naphthalenediamine 
 0.14      
 50 1023 400 0.391 8.00 25.8 7.292 
 0.47      
 50 1016 417 0.410 8.34 25.8 12.623 
1.4       
 50 1013 485 0.479 9.70 25.8 31.376 
4.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1014 462 0.456 9.24 25.8 25.022
Mitomycin-C 
 0.01      
 5 105 228 2.171 45.60 25.8 495.840
Trend: 4.010        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/03/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 522 145 0.278 5.80 25.7 0.000
Test Chemical 1,5-Naphthalenediamine 
10         
 25 525 176 0.335 7.04 25.7 20.686 
15         
 25 523 200 0.382 8.00 25.7 37.667 
20         
 25 523 261 0.499 10.44 25.7 79.656
Positive Control Mitomycin-C 
 0.001     
 25 522 307 0.588 12.28 25.7 111.724
Mitomycin-C 
 0.01      
 5 102 182 1.784 36.40 25.7 542.353
Trend: 5.860        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/02/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1010 359 0.355 7.18 25.8 0.000
Test Chemical 1,5-Naphthalenediamine 
 0.047     
 25 506 204 0.403 8.16 25.8 13.424 
 0.14      
 13 260 118 0.454 9.08 25.8 27.684 
 0.47      
 9 184 98 0.533 10.89 25.8 49.843 
1.4       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1016 576 0.567 11.52 25.8 59.498
Cyclophosphamide 
2         
 5 102 160 1.569 32.00 25.8 341.313
Trend: 3.861        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/03/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 524 140 0.267 5.60 25.7 0.000
Test Chemical 1,5-Naphthalenediamine 
 0.05      
 25 525 177 0.337 7.08 25.7 26.188 
 0.1       
 25 524 167 0.319 6.68 25.7 19.286 
 0.15      
 25 523 180 0.344 7.20 25.7 28.817 
 0.25      
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 25 525 332 0.632 13.28 25.7 136.691
Cyclophosphamide 
2         
 5 102 152 1.490 30.40 25.7 457.759
Trend: 1.875        
Probability: 0.030