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Study Information
Study Attribute Value
CEBS Accession Number: 002-01099-0001-0000-2
Chemical Name: 1,6-Hexanediamine
CASRN: 124-09-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 780219_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/24/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 440 0.419 8.80 26.0 0.000
Test Chemical 1,6-Hexanediamine 
16         
 50 1050 402 0.383 8.04 26.0 -8.723 
50         
 50 1048 396 0.378 7.92 26.0 -9.914 
160         
 50 1049 394 0.376 7.88 26.0 -10.455 
500         
 50 1047 490 0.468 9.80 26.0 11.576
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 568 0.541 11.36 26.0 28.968
Mitomycin-C 
 0.005     
 10 209 213 1.019 21.30 26.0 142.972
Trend: 1.442        
Probability: 0.075        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/23/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1053 355 0.337 7.10 26.0 0.000
Test Chemical 1,6-Hexanediamine 
5         
 50 1049 382 0.364 7.64 26.5 8.016 
160         
 13 270 99 0.367 7.62 26.5 8.761 
500         
 50 1047 402 0.384 8.04 26.5 13.888
Positive Control Cyclophosphamide 
 0.1       
 50 1049 522 0.498 10.44 26.0 47.603
Cyclophosphamide 
 0.6       
 10 210 269 1.281 26.90 26.0 279.956
Trend: 1.697        
Probability: 0.045        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/24/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 416 0.397 8.32 26.0 0.000
Test Chemical 1,6-Hexanediamine 
50         
 50 1049 419 0.399 8.38 26.0 0.625 
160         
 50 1047 404 0.386 8.08 26.0 -2.792 
500         
 50 1049 388 0.370 7.76 26.0 -6.820 
1000         
 50 1042 423 0.406 8.46 26.0 2.268
Positive Control Cyclophosphamide 
 0.1       
 50 1051 513 0.488 10.26 26.0 22.965
Cyclophosphamide 
 0.6       
 10 210 236 1.124 23.60 26.0 183.114
Trend: -0.306        
Probability: 0.620