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Study Information
Study Attribute Value
CEBS Accession Number: 002-01099-0002-0000-3
Chemical Name: 1,6-Hexanediamine
CASRN: 124-09-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 780219_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/29/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 1,6-Hexanediamine 
160         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
300         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
500         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 35 0.175 16.5 11 0.055 5.5 24 0.120 11.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 26 0.520 32.0 9 0.180 16.0 17 0.340 20.0 0 0.000 0.0
Trend: 0.942 0.000 1.354  
Probability: 0.173 0.000 0.088  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/03/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: 1,6-Hexanediamine 
160         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
300         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
500         
 200 9 0.045 4.5 2 0.010 1.0 7 0.035 3.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 37 0.185 17.0 9 0.045 4.5 28 0.140 13.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 19 0.380 34.0 4 0.080 8.0 15 0.300 28.0 0 0.000 0.0
Trend: 1.664 0.728 1.491  
Probability: 0.048 0.233 0.068  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/29/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 1,6-Hexanediamine 
160         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
300         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 200 28 0.140 4.0 1 0.005 0.5 7 0.035 3.0 20 0.100 2.0
Positive Control: Cyclophosphamide 
2.5       
 200 39 0.195 17.5 10 0.050 5.0 29 0.145 13.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 24 0.480 38.0 10 0.200 14.0 14 0.280 24.0 0 0.000 0.0
Trend: 1.772 1.305 1.132  
Probability: 0.038 0.096 0.129