COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01102-0001-0000-7
Chemical Name: 1,8-Cineol
CASRN: 470-82-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 590755_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/13/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1020 429 0.421 8.58 25.5 0.000
Test Chemical 1,8-Cineol 
50         
 50 1033 439 0.425 8.78 25.5 1.043 
150         
 50 1041 519 0.499 10.38 36.0 18.539 
500         
 50 1039 593 0.571 11.86 36.0 35.701
Positive Control Mitomycin-C 
 0.005     
 25 516 749 1.452 29.96 25.5 245.124
Trend: 5.449        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/03/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1026 388 0.378 7.76 25.5 0.000
Test Chemical 1,8-Cineol 
100         
 50 1029 439 0.427 8.78 32.5 12.814 
200         
 50 1025 541 0.528 10.82 34.5 39.569 
400         
 50 1025 534 0.521 10.68 34.5 37.763 
500         
 0 0 0 0.000 0.00 0.0 N/A 
600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 521 670 1.286 26.80 25.5 240.058
Trend: 5.498        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/27/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1033 620 0.600 12.40 25.5 0.000
Test Chemical 1,8-Cineol 
600         
 50 1029 690 0.671 13.80 25.5 11.723 
700         
 50 1021 714 0.699 14.28 25.5 16.515 
800         
 50 1032 667 0.646 13.34 25.5 7.685 
900         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 522 1006 1.927 40.24 25.5 221.097
Trend: 1.498        
Probability: 0.067