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Study Information
Study Attribute Value
CEBS Accession Number: 002-01103-0001-0000-8
Chemical Name: 1,8-Dihydroxy-4,5-dinitroanthraquinone
CASRN: 81-55-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 739395_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/11/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 342 0.328 6.84 25.3 -25.523
Dimethyl Sulfoxide 
0         
 50 1038 457 0.440 9.14 25.3 0.000
Test Chemical 1,8-Dihydroxy-4,5-dinitroanthraquinone 
 0.45      
 50 1045 776 0.743 15.52 32.3 68.666 
1.5       
 50 1042 860 0.825 17.20 32.3 87.461 
4.5       
 13 273 269 0.985 20.69 32.3 123.806 
15         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1036 505 0.487 10.10 25.3 10.717
Mitomycin-C 
 0.01      
 5 105 196 1.867 39.20 25.3 323.982
Trend: 12.060        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 01/15/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 388 0.374 7.76 26.0 0.000
Test Chemical 1,8-Dihydroxy-4,5-dinitroanthraquinone 
1.2       
 50 1045 834 0.798 16.68 32.3 113.509 
2.3       
 50 1051 866 0.824 17.32 32.3 120.435 
4.6       
 50 1046 1018 0.973 20.36 32.3 160.364 
9         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 564 0.538 11.28 26.0 43.837
Mitomycin-C 
 0.01      
 5 106 217 2.047 43.40 26.0 447.671
Trend: 15.265        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/11/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 405 0.387 8.10 25.3 0.000
Test Chemical 1,8-Dihydroxy-4,5-dinitroanthraquinone 
 0.15      
 50 1050 425 0.405 8.50 32.3 4.638 
 0.45      
 50 1043 468 0.449 9.36 32.3 15.999 
1.5       
 50 1051 556 0.529 11.12 32.3 36.761 
4.5       
 50 1030 1175 1.141 23.50 32.3 194.912 
15         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1052 673 0.640 13.46 25.3 65.383
Cyclophosphamide 
2         
 5 105 178 1.695 35.60 25.3 338.250
Trend: 21.686        
Probability: 0.000