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Study Information
Study Attribute Value
CEBS Accession Number: 002-01103-0002-0000-9
Chemical Name: 1,8-Dihydroxy-4,5-dinitroanthraquinone
CASRN: 81-55-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 739395_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 02/19/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 3.0 2 0.020 2.0 4 0.040 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,8-Dihydroxy-4,5-dinitroanthraquinone 
5         
 100 10 0.100 10.0 5 0.050 5.0 5 0.050 5.0 0 0.000 0.0 
10.1       
 50 36 0.720 46.0 12 0.240 16.0 24 0.480 36.0 0 0.000 0.0 
15.1       
 25 68 2.720 76.0 4 0.160 12.0 54 2.160 72.0 10 0.400 4.0 
20.1       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 12 0.120 12.0 3 0.030 3.0 8 0.080 8.0 1 0.010 1.0
Mitomycin-C 
 0.063     
 50 12 0.240 14.0 4 0.080 8.0 8 0.160 8.0 0 0.000 0.0
Trend: 9.121 2.606 9.709  
Probability: 0.000 0.005 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/29/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,8-Dihydroxy-4,5-dinitroanthraquinone 
7.4       
 100 15 0.150 13.0 4 0.040 4.0 11 0.110 9.0 0 0.000 0.0 
10.1       
 100 19 0.190 12.0 6 0.060 6.0 13 0.130 10.0 0 0.000 0.0 
24.8       
 100 73 0.730 41.0 37 0.370 25.0 36 0.360 27.0 0 0.000 0.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 18 0.180 16.0 3 0.030 3.0 15 0.150 14.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 38 1.520 60.0 13 0.520 36.0 25 1.000 56.0 0 0.000 0.0
Trend: 7.409 6.176 5.776  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 01/29/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 8 0.080 8.0 5 0.050 5.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 12 0.120 7.0 2 0.020 2.0 10 0.100 5.0 0 0.000 0.0
Test Chemical: 1,8-Dihydroxy-4,5-dinitroanthraquinone 
10.1       
 25 39 1.560 76.0 6 0.240 20.0 33 1.320 92.0 0 0.000 0.0 
12.4       
 25 75 3.000 76.0 4 0.160 16.0 49 1.960 56.0 22 0.880 16.0 
15         
 22 93 4.227 91.0 5 0.227 18.0 47 2.136 63.0 41 1.864 23.0
Positive Control: Mitomycin-C 
 0.04      
 100 15 0.150 13.0 8 0.080 6.0 7 0.070 7.0 0 0.000 0.0
Mitomycin-C 
 0.063     
 25 15 0.600 40.0 4 0.160 12.0 11 0.440 32.0 0 0.000 0.0
Trend: 9.132 3.109 6.933  
Probability: 0.000 0.001 0.000