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Study Information
Study Attribute Value
CEBS Accession Number: 002-01108-0001-0000-3
Chemical Name: 1-Amino-2,4-dibromoanthraquinone
CASRN: 81-49-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 438792_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 12/09/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 335 0.320 6.70 26.0 0.000
Test Chemical 1-Amino-2,4-dibromoanthraquinone 
2.5       
 50 1037 355 0.342 7.10 26.0 6.890 
5         
 50 1040 395 0.380 7.90 26.0 18.591 
10         
 50 1043 436 0.418 8.72 26.0 30.524
Positive Control Mitomycin-C 
 0.002     
 50 1041 567 0.545 11.34 26.0 70.067
Mitomycin-C 
 0.01      
 10 208 243 1.168 24.30 26.0 264.779
Trend: 3.954        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/11/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 420 0.401 8.40 26.0 0.000
Test Chemical 1-Amino-2,4-dibromoanthraquinone 
3.01      
 50 1044 528 0.506 10.56 26.0 26.076 
10.1       
 50 1047 581 0.555 11.62 26.0 38.333 
30.1       
 50 1048 597 0.570 11.94 26.0 42.007
Positive Control Cyclophosphamide 
 0.5       
 50 1038 642 0.618 12.84 26.0 54.182
Cyclophosphamide 
2.5       
 10 206 291 1.413 29.10 26.0 252.146
Trend: 5.652        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/09/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 402 0.390 8.04 26.0 0.000
Test Chemical 1-Amino-2,4-dibromoanthraquinone 
7.5       
 50 1041 440 0.423 8.80 26.0 8.506 
10         
 50 1041 452 0.434 9.04 26.0 11.466 
15         
 50 1043 501 0.480 10.02 26.0 23.312
Positive Control Cyclophosphamide 
 0.5       
 50 1044 593 0.568 11.86 26.0 45.817
Cyclophosphamide 
2.5       
 10 207 248 1.198 24.80 26.0 207.564
Trend: 3.151        
Probability: 0.001