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Study Information
Study Attribute Value
CEBS Accession Number: 002-01108-0002-0000-4
Chemical Name: 1-Amino-2,4-dibromoanthraquinone
CASRN: 81-49-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 438792_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 11/20/1986    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1-Amino-2,4-dibromoanthraquinone 
3.02      
 200 7 0.035 3.0 1 0.005 0.5 6 0.030 2.5 0 0.000 0.0 
10.1       
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
30.2       
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 51 0.255 20.5 17 0.085 8.0 33 0.165 14.0 1 0.005 1.0
Mitomycin-C 
5         
 50 47 0.940 56.0 19 0.380 32.0 28 0.560 38.0 0 0.000 0.0
Trend: 0.977 0.015 1.048  
Probability: 0.164 0.494 0.147  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/20/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 2 0.010 1.0 1 0.005 0.5 1 0.005 1.0
Test Chemical: 1-Amino-2,4-dibromoanthraquinone 
3.02      
 200 9 0.045 4.0 3 0.015 1.5 6 0.030 3.0 0 0.000 0.0 
10.1       
 200 13 0.065 5.5 1 0.005 0.5 11 0.055 4.5 1 0.005 1.0 
30.2       
 200 7 0.035 3.5 3 0.015 1.5 4 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 25 0.500 34.0 8 0.160 10.0 17 0.340 28.0 0 0.000 0.0
Trend: 1.022 0.131 1.248  
Probability: 0.153 0.448 0.106  


Trial #:2   Activation: No Activation    Date: 10/27/1988    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 2.0 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0
Test Chemical: 1-Amino-2,4-dibromoanthraquinone 
1         
 200 12 0.060 5.0 2 0.010 1.0 8 0.040 3.5 2 0.010 2.0 
3         
 200 18 0.090 6.0 5 0.025 2.0 13 0.065 4.0 0 0.000 0.0 
10         
 200 11 0.055 4.5 5 0.025 2.0 6 0.030 3.0 0 0.000 0.0 
30         
 200 6 0.030 2.0 0 0.000 0.0 6 0.030 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 171 0.855 40.5 44 0.220 17.5 66 0.330 25.5 61 0.305 7.0
Mitomycin-C 
5         
 50 41 0.820 56.0 22 0.440 36.0 19 0.380 30.0 0 0.000 0.0
Trend: -0.126 0.000 -0.141  
Probability: 0.550 0.500 0.556