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Study Information
Study Attribute Value
CEBS Accession Number: 002-01108-0003-0000-5
Chemical Name: 1-Amino-2,4-dibromoanthraquinone
CASRN: 81-49-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 905842_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/17/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 435 0.415 8.70 26.0 0.000
Test Chemical 1-Amino-2,4-dibromoanthraquinone 
1.6       
 50 1043 516 0.495 10.32 26.0 19.303 
5         
 50 1041 526 0.505 10.52 26.0 21.849 
16         
 50 1048 565 0.539 11.30 26.0 30.009 
50         
 14 290 171 0.590 12.21 26.0 42.195
Positive Control Mitomycin-C 
 0.0E-4    
 50 1039 591 0.569 11.82 26.0 37.170
Mitomycin-C 
 0.005     
 10 210 194 0.924 19.40 26.0 122.776
Trend: 4.606        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/22/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 468 0.447 9.36 26.0 0.000
Test Chemical 1-Amino-2,4-dibromoanthraquinone 
1.6       
 50 1046 515 0.492 10.30 26.0 10.148 
5         
 50 1044 538 0.515 10.76 26.0 15.288 
16         
 50 1047 554 0.529 11.08 26.0 18.376 
50         
 13 267 147 0.551 11.31 26.0 23.171
Positive Control Mitomycin-C 
 0.0E-4    
 50 1043 574 0.550 11.48 26.0 23.120
Mitomycin-C 
 0.005     
 10 210 273 1.300 27.30 26.0 190.833
Trend: 3.006        
Probability: 0.001        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/17/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 432 0.411 8.64 26.0 0.000
Test Chemical 1-Amino-2,4-dibromoanthraquinone 
5         
 50 1049 412 0.393 8.24 26.0 -4.448 
16         
 50 1050 465 0.443 9.30 26.0 7.741 
50         
 50 1040 489 0.470 9.78 26.0 14.392 
100         
 50 1050 480 0.457 9.60 26.0 11.217
Positive Control Cyclophosphamide 
 0.1       
 50 1046 546 0.522 10.92 26.0 26.993
Cyclophosphamide 
 0.6       
 10 210 193 0.919 19.30 26.0 123.592
Trend: 2.728        
Probability: 0.003