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Study Information
Study Attribute Value
CEBS Accession Number: 002-01108-0004-0000-6
Chemical Name: 1-Amino-2,4-dibromoanthraquinone
CASRN: 81-49-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 905842_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 01/12/1988    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: 1-Amino-2,4-dibromoanthraquinone 
16         
 200 12 0.060 5.0 3 0.015 1.5 9 0.045 3.5 0 0.000 0.0 
30         
 200 9 0.045 4.5 0 0.000 0.0 9 0.045 4.5 0 0.000 0.0 
50         
 200 13 0.065 6.0 1 0.005 0.5 12 0.060 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 25 0.125 12.5 5 0.025 2.5 20 0.100 10.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 21 0.420 36.0 4 0.080 6.0 17 0.340 32.0 0 0.000 0.0
Trend: 1.762 -0.046 2.091  
Probability: 0.039 0.518 0.018  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/17/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: 1-Amino-2,4-dibromoanthraquinone 
16         
 200 3 0.015 0.5 0 0.000 0.0 3 0.015 0.5 0 0.000 0.0 
50         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
100         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 15 0.075 7.0 4 0.020 2.0 11 0.055 5.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 19 0.380 36.0 1 0.020 2.0 18 0.360 34.0 0 0.000 0.0
Trend: 0.084 0.000 0.084  
Probability: 0.467 0.000 0.467  


Trial #:2   Activation: No Activation    Date: 12/17/1987    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 1-Amino-2,4-dibromoanthraquinone 
5         
 200 7 0.035 3.5 1 0.005 0.5 6 0.030 3.0 0 0.000 0.0 
16         
 200 9 0.045 4.0 1 0.005 0.5 8 0.040 3.5 0 0.000 0.0 
50         
 200 12 0.060 5.5 2 0.010 1.0 10 0.050 4.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 23 0.115 10.0 2 0.010 1.0 21 0.105 9.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 18 0.360 32.0 4 0.080 6.0 14 0.280 28.0 0 0.000 0.0
Trend: 2.114 1.344 1.726  
Probability: 0.017 0.090 0.042