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Study Information
Study Attribute Value
CEBS Accession Number: 002-01109-0001-0000-4
Chemical Name: 1-Amino-2-methylanthraquinone
CASRN: 82-28-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 587359_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/24/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 392 0.374 7.84 26.0 0.000
Test Chemical 1-Amino-2-methylanthraquinone 
 0.5       
 50 1049 457 0.436 9.14 26.0 16.582 
1.6       
 50 1050 469 0.447 9.38 26.0 19.529 
5         
 50 1050 501 0.477 10.02 26.0 27.684 
16         
 50 1047 599 0.572 11.98 26.0 53.098
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 507 0.483 10.14 26.0 29.337
Mitomycin-C 
 0.005     
 10 210 266 1.267 26.60 26.0 238.963
Trend: 6.609        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/24/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 411 0.391 8.22 26.0 0.000
Test Chemical 1-Amino-2-methylanthraquinone 
16         
 50 1050 410 0.390 8.20 26.0 -0.148 
50         
 50 1048 526 0.502 10.52 26.0 28.347 
160         
 50 1049 765 0.729 15.30 26.0 86.486 
500         
 23 483 344 0.712 14.96 26.0 82.126
Positive Control Cyclophosphamide 
 0.15      
 50 1050 556 0.530 11.12 26.0 35.409
Cyclophosphamide 
 0.6       
 10 210 240 1.143 24.00 26.0 192.249
Trend: 12.666        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/30/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 385 0.367 7.70 26.0 0.000
Test Chemical 1-Amino-2-methylanthraquinone 
16         
 50 1049 539 0.514 10.78 26.0 40.000 
50         
 50 1052 564 0.536 11.28 26.0 46.076 
160         
 50 1049 787 0.750 15.74 26.0 104.416 
500         
 0 0 0 0.000 0.00 31.0 N/A 
500         
 16 330 256 0.776 16.00 26.0 111.369
Positive Control Cyclophosphamide 
 0.1       
 50 1051 513 0.488 10.26 26.0 32.993
Cyclophosphamide 
 0.6       
 10 210 254 1.210 25.40 26.0 229.556
Trend: 12.514        
Probability: 0.000