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Study Information
Study Attribute Value
CEBS Accession Number: 002-01109-0002-0000-5
Chemical Name: 1-Amino-2-methylanthraquinone
CASRN: 82-28-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 587359_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 06/11/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 1-Amino-2-methylanthraquinone 
50         
 200 5 0.025 2.0 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0 
100         
 200 8 0.040 4.0 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0 
160         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 38 0.190 17.0 12 0.060 6.0 26 0.130 12.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 22 0.440 36.0 11 0.220 16.0 11 0.220 22.0 0 0.000 0.0
Trend: 1.700 1.364 0.892  
Probability: 0.045 0.086 0.186  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/11/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: 1-Amino-2-methylanthraquinone 
160         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
300         
 200 19 0.095 8.5 3 0.015 1.5 16 0.080 7.0 0 0.000 0.0 
500         
 200 18 0.090 6.0 6 0.030 2.5 12 0.060 4.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 47 0.235 21.0 13 0.065 6.5 34 0.170 15.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 17 0.340 30.0 4 0.080 8.0 13 0.260 24.0 0 0.000 0.0
Trend: 3.293 2.247 2.878  
Probability: 0.000 0.012 0.002  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/23/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 1-Amino-2-methylanthraquinone 
160         
 200 18 0.090 8.0 3 0.015 1.5 15 0.075 7.0 0 0.000 0.0 
300         
 200 19 0.095 8.0 4 0.020 2.0 15 0.075 6.5 0 0.000 0.0 
500         
 200 17 0.085 8.0 2 0.010 1.0 15 0.075 7.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 39 0.195 18.5 7 0.035 3.5 32 0.160 16.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 20 0.400 30.0 4 0.080 6.0 16 0.320 28.0 0 0.000 0.0
Trend: 2.760 1.092 2.459  
Probability: 0.003 0.138 0.007