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Study Information
Study Attribute Value
CEBS Accession Number: 002-01111-0001-0000-7
Chemical Name: 1-Aziridineethanol
CASRN: 1072-52-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 346199_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/02/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 327 0.312 6.54 25.5 0.000
Test Chemical 1-Aziridineethanol 
2         
 50 1048 659 0.629 13.18 25.5 101.337 
6.7       
 10 209 319 1.526 31.90 25.5 388.701 
20.1       
 10 210 506 2.410 50.60 25.5 671.490 
67.1       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 599 0.573 11.98 25.5 83.356
Mitomycin-C 
 0.01      
 5 105 261 2.486 52.20 25.5 695.885
Trend: 34.117        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/23/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 394 0.376 7.88 25.5 0.000
Test Chemical 1-Aziridineethanol 
 0.75      
 25 523 664 1.270 26.56 25.5 238.023 
1         
 25 525 854 1.627 34.16 25.5 333.090 
5.1       
 5 104 506 4.865 101.20 34.0 1195.378 
10.2       
 0 0 0 0.000 0.00 34.0 N/A 
15.2       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 625 0.596 12.50 25.5 58.781
Mitomycin-C 
 0.01      
 5 105 237 2.257 47.40 25.5 500.950
Trend: 43.796        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/02/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1050 367 0.350 7.34 25.5 0.000
Test Chemical 1-Aziridineethanol 
20.1       
 50 1049 555 0.529 11.10 25.5 51.370 
67.1       
 50 1049 898 0.856 17.96 25.5 144.920 
201.4       
 10 210 302 1.438 30.20 25.5 311.444 
671.3       
 0 0 0 0.000 0.00 25.5 N/A 
2010         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1048 550 0.525 11.00 25.5 50.150
Cyclophosphamide 
2         
 5 105 151 1.438 30.20 25.5 311.444
Trend: 20.329        
Probability: 0.000