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Study Information
Study Attribute Value
CEBS Accession Number: 002-01111-0002-0000-8
Chemical Name: 1-Aziridineethanol
CASRN: 1072-52-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 346199_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 11/14/1984    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 50 3 0.060 6.0 2 0.040 4.0 1 0.020 2.0 0 0.000 0.0
Medium 
0         
 50 1 0.020 2.0 0 0.000 0.0 1 0.020 2.0 0 0.000 0.0
Test Chemical: 1-Aziridineethanol 
6.3       
 50 6 0.120 12.0 1 0.020 2.0 5 0.100 10.0 0 0.000 0.0 
12.5       
 25 12 0.480 32.0 6 0.240 20.0 6 0.240 24.0 0 0.000 0.0 
25         
 25 18 0.720 60.0 12 0.480 40.0 6 0.240 20.0 0 0.000 0.0 
50.1       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 15 0.300 26.0 5 0.100 10.0 10 0.200 18.0 0 0.000 0.0
Mitomycin-C 
 0.5       
 25 15 0.600 48.0 7 0.280 24.0 8 0.320 24.0 0 0.000 0.0
Trend: 6.121 5.534 2.934  
Probability: 0.000 0.000 0.002  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/30/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1-Aziridineethanol 
1200         
 10 92 9.200 100.0 2 0.200 10.0 0 0.000 0.0 90 9.000 90.0 
1500         
 10 93 9.300 100.0 2 0.200 10.0 1 0.100 10.0 90 9.000 90.0 
1800         
 10 79 7.900 100.0 1 0.100 10.0 7 0.700 20.0 71 7.100 80.0 
2000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 15 0.150 12.0 6 0.060 6.0 9 0.090 6.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 9 0.360 36.0 4 0.160 16.0 5 0.200 20.0 0 0.000 0.0
Trend: 10.207 2.864 4.189  
Probability: 0.000 0.002 0.000  


Trial #:2   Activation: No Activation    Date: 10/31/1984    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 2.0 1 0.010 1.0 3 0.030 2.0 0 0.000 0.0
Medium 
0         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 1-Aziridineethanol 
6.3       
 100 30 0.300 16.0 6 0.060 6.0 13 0.130 9.0 11 0.110 2.0 
12.6       
 25 34 1.360 36.0 4 0.160 12.0 8 0.320 20.0 22 0.880 16.0 
25.3       
 25 51 2.040 48.0 0 0.000 0.0 10 0.400 28.0 41 1.640 20.0
Positive Control: Mitomycin-C 
 0.15      
 100 25 0.250 18.0 8 0.080 8.0 17 0.170 10.0 0 0.000 0.0
Mitomycin-C 
 0.5       
 25 33 1.320 56.0 6 0.240 20.0 7 0.280 28.0 20 0.800 8.0
Trend: 5.992 0.685 4.476  
Probability: 0.000 0.247 0.000