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Study Information
Study Attribute Value
CEBS Accession Number: 002-01111-0003-0000-9
Chemical Name: 1-Aziridineethanol
CASRN: 1072-52-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 698839_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/28/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1032 425 0.412 8.50 25.5 0.000
Test Chemical 1-Aziridineethanol 
 0.173     
 50 1035 886 0.856 17.72 25.5 107.866 
 0.578     
 10 203 494 2.433 49.40 25.5 490.910 
1.7       
 10 207 510 2.464 51.00 25.5 498.261 
5.8       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1036 780 0.753 15.60 25.5 82.821
Mitomycin-C 
 0.01      
 5 101 316 3.129 63.20 25.5 659.725
Trend: 34.319        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/31/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 25 518 209 0.403 8.36 25.5 0.000
Test Chemical 1-Aziridineethanol 
2         
 10 207 679 3.280 67.90 25.5 712.986 
3         
 10 207 925 4.469 92.50 33.0 1007.528 
4         
 10 206 1161 5.636 116.10 33.0 1296.846 
5         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 25 522 358 0.686 14.32 25.5 69.979
Mitomycin-C 
 0.01      
 5 105 261 2.486 52.20 25.5 516.077
Trend: 43.538        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/28/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1031 467 0.453 9.34 25.5 0.000
Test Chemical 1-Aziridineethanol 
5.8       
 10 210 254 1.210 25.40 25.5 167.028 
17.3       
 10 204 239 1.172 23.90 25.5 158.648 
57.8       
 10 209 557 2.665 55.70 33.5 488.370 
173.4       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1047 658 0.628 13.16 25.5 38.746
Cyclophosphamide 
2         
 5 103 165 1.602 33.00 25.5 253.662
Trend: 29.803        
Probability: 0.000