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Study Information
Study Attribute Value
CEBS Accession Number: 002-01111-0004-0000-0
Chemical Name: 1-Aziridineethanol
CASRN: 1072-52-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 698839_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 09/20/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1-Aziridineethanol 
6         
 50 11 0.220 18.0 6 0.120 10.0 5 0.100 8.0 0 0.000 0.0 
8         
 50 20 0.400 26.0 7 0.140 14.0 13 0.260 20.0 0 0.000 0.0 
10.4       
 25 31 1.240 44.0 14 0.560 36.0 17 0.680 28.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 50 15 0.300 22.0 8 0.160 14.0 7 0.140 14.0 0 0.000 0.0
Mitomycin-C 
 0.062     
 25 19 0.760 52.0 6 0.240 20.0 13 0.520 40.0 0 0.000 0.0
Trend: 5.992 5.408 4.902  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/29/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Medium 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 1-Aziridineethanol 
100.5       
 10 94 9.400 100.0 4 0.400 10.0 0 0.000 0.0 90 9.000 90.0 
149.4       
 10 77 7.700 80.0 7 0.700 10.0 0 0.000 0.0 70 7.000 70.0 
201         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 8 0.080 8.0 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 10 0.400 28.0 1 0.040 4.0 9 0.360 24.0 0 0.000 0.0
Trend: 8.247 2.186 -0.592  
Probability: 0.000 0.014 0.723  


Trial #:2   Activation: No Activation    Date: 08/29/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1-Aziridineethanol 
5.9       
 25 15 0.600 44.0 8 0.320 32.0 7 0.280 20.0 0 0.000 0.0 
7         
 25 34 1.360 52.0 18 0.720 40.0 16 0.640 36.0 0 0.000 0.0 
8.1       
 25 45 1.800 60.0 16 0.640 48.0 9 0.360 20.0 20 0.800 8.0
Positive Control: Mitomycin-C 
 0.04      
 100 23 0.230 21.0 15 0.150 14.0 8 0.080 7.0 0 0.000 0.0
Mitomycin-C 
 0.062     
 25 21 0.840 48.0 12 0.480 40.0 9 0.360 28.0 0 0.000 0.0
Trend: 7.856 6.836 4.748  
Probability: 0.000 0.000 0.000