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Study Information
Study Attribute Value
CEBS Accession Number: 002-01116-0001-0000-2
Chemical Name: 1-Chloro-2-propanol
CASRN: 127-00-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 794630_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 04/02/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1025 366 0.357 7.32 25.5 0.000
Test Chemical 1-Chloro-2-propanol 
167         
 50 1051 506 0.481 10.12 25.5 34.831 
500         
 25 517 543 1.050 21.72 25.5 194.139 
1700         
 25 527 675 1.281 27.00 33.5 258.704
Positive Control Mitomycin-C 
 0.001     
 50 1035 637 0.615 12.74 25.5 72.362
Mitomycin-C 
 0.01      
 5 104 236 2.269 47.20 25.5 535.509
Trend: 23.729        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/23/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1052 357 0.339 7.14 26.0 0.000
Test Chemical 1-Chloro-2-propanol 
1700         
 10 211 309 1.464 30.90 34.0 331.542 
3000         
 5 105 175 1.667 35.00 34.0 391.130 
4000         
 5 106 185 1.745 37.00 34.0 414.296 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 599 0.570 11.98 26.0 68.107
Mitomycin-C 
 0.01      
 5 105 223 2.124 44.60 26.0 525.840
Trend: 23.693        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/02/1985    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1039 398 0.383 7.96 25.5 0.000
Test Chemical 1-Chloro-2-propanol 
167         
 50 1046 373 0.357 7.46 25.5 -6.909 
500         
 50 1041 431 0.414 8.62 25.5 8.083 
1700         
 50 1041 664 0.638 13.28 33.5 66.514 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1046 626 0.598 12.52 25.5 56.234
Cyclophosphamide 
2         
 5 105 218 2.076 43.60 25.5 442.000
Trend: 8.981        
Probability: 0.000