COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01116-0002-0000-3
Chemical Name: 1-Chloro-2-propanol
CASRN: 127-00-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 794630_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 08/01/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 1-Chloro-2-propanol 
3000         
 50 5 0.100 10.0 1 0.020 2.0 4 0.080 8.0 0 0.000 0.0 
4000         
 50 11 0.220 18.0 1 0.020 2.0 10 0.200 16.0 0 0.000 0.0 
5000         
 50 12 0.240 22.0 4 0.080 8.0 8 0.160 14.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 50 27 0.540 32.0 6 0.120 12.0 21 0.420 22.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 22 0.880 52.0 7 0.280 28.0 15 0.600 44.0 0 0.000 0.0
Trend: 3.865 2.120 3.134  
Probability: 0.000 0.017 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/05/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 11 0.055 3.5 0 0.000 0.0 9 0.045 3.5 2 0.010 1.0
Medium 
0         
 200 10 0.050 4.0 5 0.025 2.5 4 0.020 1.5 1 0.005 0.5
Test Chemical: 1-Chloro-2-propanol 
3000         
 20 47 2.350 75.0 15 0.750 40.0 22 1.100 60.0 10 0.500 5.0 
4000         
 20 74 3.700 95.0 21 1.050 55.0 33 1.650 80.0 20 1.000 10.0 
5000         
 20 79 3.950 90.0 20 1.000 55.0 37 1.850 80.0 22 1.100 20.0
Positive Control: Cyclophosphamide 
6.25      
 200 57 0.285 22.0 17 0.085 7.5 39 0.195 17.0 1 0.005 0.5
Cyclophosphamide 
12.5       
 25 18 0.720 40.0 6 0.240 24.0 12 0.480 32.0 0 0.000 0.0
Trend: 12.623 9.199 12.244  
Probability: 0.000 0.000 0.000