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Study Information
Study Attribute Value
CEBS Accession Number: 002-01124-0001-0000-1
Chemical Name: 1-Naphthylamine
CASRN: 134-32-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 062447_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/11/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 502 0.479 10.04 26.0 0.000
Test Chemical 1-Naphthylamine 
1.6       
 50 1048 492 0.469 9.84 26.0 -1.992 
5         
 50 1047 554 0.529 11.08 26.0 10.464 
16         
 50 1051 554 0.527 11.08 26.0 10.044 
50         
 50 1049 634 0.604 12.68 26.0 26.174 
160         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1052 623 0.592 12.46 26.0 23.632
Mitomycin-C 
 0.005     
 10 209 259 1.239 25.90 26.0 158.709
Trend: 4.367        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/16/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 512 0.489 10.24 26.0 0.000
Test Chemical 1-Naphthylamine 
25         
 50 1048 631 0.602 12.62 26.0 23.125 
50         
 50 1049 695 0.663 13.90 31.0 35.483 
75         
 50 1053 817 0.776 16.34 31.0 58.661 
100         
 50 1051 828 0.788 16.56 31.0 61.103 
125         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 626 0.596 12.52 26.0 21.916
Mitomycin-C 
 0.005     
 10 210 301 1.433 30.10 26.0 193.105
Trend: 9.729        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 08/27/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 443 0.422 8.86 26.0 0.000
Test Chemical 1-Naphthylamine 
25         
 50 1049 654 0.623 13.08 26.0 47.630 
50         
 50 1052 655 0.623 13.10 31.0 47.434 
75         
 50 1050 754 0.718 15.08 31.0 70.041 
100         
 50 1051 864 0.822 17.28 31.0 94.663 
125         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 582 0.555 11.64 26.0 31.377
Mitomycin-C 
 0.005     
 10 210 230 1.095 23.00 26.0 159.346
Trend: 11.077        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/11/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 499 0.479 9.98 26.0 0.000
Test Chemical 1-Naphthylamine 
 0.5       
 50 1050 459 0.437 9.18 26.0 -8.804 
1.6       
 50 1041 491 0.472 9.82 26.0 -1.603 
5         
 50 1045 500 0.478 10.00 26.0 -0.183 
16         
 50 1049 507 0.483 10.14 26.0 0.828
Positive Control Cyclophosphamide 
 0.2       
 50 1049 980 0.934 19.60 26.0 94.895
Cyclophosphamide 
 0.6       
 10 211 264 1.251 26.40 26.0 161.019
Trend: 0.739        
Probability: 0.230