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Study Information
Study Attribute Value
CEBS Accession Number: 002-01124-0002-0000-2
Chemical Name: 1-Naphthylamine
CASRN: 134-32-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 062447_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Weakly Positive* 
Induced Rat Liver S9  2_S9  Positive 
No Activation  3  Negative 

Trial #:1   Activation: No Activation    Date: 10/23/1985    Harvest Time: 17.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.0 0 0.000 0.0 3 0.015 1.0 0 0.000 0.0
Test Chemical: 1-Naphthylamine 
200         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
250         
 200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0 
300         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0 
350         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 68 0.340 24.0 37 0.185 15.0 21 0.105 10.0 10 0.050 1.0
Mitomycin-C 
 0.125     
 50 28 0.560 34.0 13 0.260 22.0 15 0.300 24.0 0 0.000 0.0
Trend: 1.666 0.007 1.769  
Probability: 0.048 0.497 0.038  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/23/1985    Harvest Time: 18 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1-Naphthylamine 
16         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
30         
 200 3 0.015 1.5 1 0.005 0.5 1 0.005 0.5 1 0.005 1.0 
50         
 200 24 0.120 7.0 8 0.040 3.5 16 0.080 6.0 0 0.000 0.0 
100         
 120 110 0.917 48.3 26 0.217 19.2 83 0.692 41.7 1 0.008 1.0
Positive Control: Cyclophosphamide 
2.5       
 200 46 0.230 19.5 13 0.065 6.5 33 0.165 14.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 54 1.080 60.0 22 0.440 36.0 22 0.440 34.0 10 0.200 1.0
Trend: 12.779 7.851 12.016  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 09/24/1985    Harvest Time: 17 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 1-Naphthylamine 
100         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
160         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0 
300         
 200 23 0.115 8.5 4 0.020 2.0 19 0.095 6.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 81 0.405 34.5 42 0.210 19.0 39 0.195 18.5 0 0.000 0.0
Mitomycin-C 
 0.125     
 50 31 0.620 48.0 17 0.340 28.0 14 0.280 26.0 0 0.000 0.0
Trend: 4.188 2.309 3.512  
Probability: 0.000 0.010 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/26/1986    Harvest Time: 18 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: 1-Naphthylamine 
75         
 200 24 0.120 9.5 9 0.045 4.0 15 0.075 6.5 0 0.000 0.0 
100         
 200 29 0.145 9.5 12 0.060 5.5 17 0.085 5.5 0 0.000 0.0 
125         
 200 74 0.370 15.5 37 0.185 12.0 27 0.135 10.0 10 0.050 1.0
Positive Control: Cyclophosphamide 
2.5       
 200 52 0.260 22.5 21 0.105 10.0 31 0.155 13.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 40 0.800 48.0 16 0.320 22.0 24 0.480 40.0 0 0.000 0.0
Trend: 4.592 4.926 3.475  
Probability: 0.000 0.000 0.000  


Trial #:3   Activation: No Activation    Date: 09/24/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: 1-Naphthylamine 
16         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
30         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
50         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 28 0.140 13.0 10 0.050 0.5 18 0.090 8.5 0 0.000 0.0
Mitomycin-C 
 0.125     
 50 16 0.320 22.0 8 0.160 14.0 8 0.160 12.0 0 0.000 0.0
Trend: -0.718 0.000 -0.961  
Probability: 0.764 0.500 0.832